Results 41 to 50 of about 183,459 (262)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Local wisdom-oriented problem solving learning model to improve mathematical problem solving ability

Journal of Technology and Science Education, 2018
The aim of this study was to describe and to test the effect of problem solving learning model oriented toward Balinese local wisdom (PSBLW) and type of mathematics problems (open and closed problems) on the ability to solve mathematics problem of the ...
Ni Nyoman Parwati, I Gusti Putu Sudiarta, I Made Mariawan, I Wayan Widiana   +3 more
doaj   +1 more source

The Comparison of Students’ Mathematical Problem Solving Ability through Students Teams Achievement Division (STAD) and Problem Based Learning (PBL)

Al-Ishlah: Jurnal Pendidikan, 2022
The purpose of the study was to determine the comparison of students’ mathematical problem-solving abilities through STAD and PBL learning models. This research was an experimental study with a nonequivalent post-test only control group design.
Chairuddin Chairuddin, Farman Farman
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Kemampuan Berpikir Kritis Mahasiswa Pendidikan Biologi Melalui Penyelesaian Masalah Lingkungan

Bioedukasi: Jurnal Pendidikan Biologi, 2018
Critical thinking ability is important to be possessed by every individual, especially in the era of globalization. The ability to think critically supports the individual to overcome the problems in life, among which environmental problems are ...
Nuzulia Santi, Mochamad Arief Soendjoto, Atiek Winarti   +2 more
doaj   +1 more source

IMPROVING MATHEMATICAL PROBLEM SOLVING ABILITIES OF THE STUDENT WITH THE PROBLEM-BASED LEARNING APPROACH

Aksioma: Jurnal Program Studi Pendidikan Matematika, 2021
This study aimed to determine the application of the problem-based learning approach to improve the mathematics problem solving skills of the fifth grade students of SDN Susukan 04. The research was conducted at SDN Susukan 04.
Lisa Virdinarti Putra, Ela Suryani, Ontya Sekar Kinasih, Wahyu Tyas Utami   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Development of Problem Based Learning Method To Increase Students’ Mathematical Problem Solving Ability at Numbers Theory Courses

International Journal of Trends in Mathematics Education Research, 2019
This article presents development reasearh result of problem based learning method to increse students’mathematical problem solving ability conducted at 4th semester students in 2016 academic years at numbers theory course.
Asep Sahrudin
doaj   +1 more source