Results 61 to 70 of about 3,575,013 (348)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

INFLUENCE OF PROBLEM POSING METHOD ON PROBLEM SOLVING SKILLS

open access: yesJurnal Pendidikan Ilmu Sosial, 2018
This study aims to analyze the difference between problem-solving ability using problem posing method and conventional method. This research was conducted at SMAN 1 Parongpong Kabupaten Bandung Barat. The research subjects were students of class X Social
Dewi Daryati
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Mathematical Communication: What And How To Develop It In Mathematics Learning? [PDF]

open access: yes, 2011
Mathematics is the language of symbols so that everyone who studied mathematics required having the ability to communicate using the language of these symbols. Mathematical communication skills will make a person could use mathematics for its own sake as
Qohar, Abd.
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Study of psychometric properties of problem-solving skills questionnaire heppner and petersen in primary school students of birjand

open access: yesمجله علوم روانشناختی, 2022
Background: Because research shows that reducing problem solving skills causes problems such as reduced academic achievement and academic achievement in elementary students. Although these dimensions and constituent components have been identified, there
shirin chaji   +3 more
doaj  

A collaborative approach to learning programming: a hybrid learning model [PDF]

open access: yes, 2005
The use of cooperative working as a means of developing collaborative skills has been recognised as vital in programming education. This paper presents results obtained from preliminary work to investigate the effectiveness of Pair Programming as a ...
Ferguson, John D.   +4 more
core  

Sensory Substitution, Key to Inclusive Learning [PDF]

open access: yes, 2020
Visually impaired students, in primary education, encounter unique challenges while learning creative skills, exploring artistic expression and developing problem-solving skills, because so much instructional content is delivered visually.
Zahir, Fathima Z
core   +1 more source

Work-in-Progress: Research Plan for Introducing Problem Solving Skills through Activities to an Introductory Computer Science Course [PDF]

open access: yes, 2019
This work-in-progress research plan paper describes the process of developing and planning an introductory computer science course utilizing fundamental problem-solving skills in combination with hands-on visual activities to explain various Computer
Coffman-Wolph, Stephany   +2 more
core   +1 more source

The effect of project based learning-STEM on problem solving skills for students in the topic of electromagnetic induction

open access: yesJournal of Physics: Conference Series, 2020
Problem solving skills is one of six topical areas of physics education research, whereas the research about implementation of Project Based Learning-Science Technology Engineering and Mathematics (PjBL-STEM) to enhance students’ problem solving skills ...
Parno   +5 more
semanticscholar   +1 more source

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