Results 61 to 70 of about 7,778,579 (239)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

ORNE Learning Model to Improve Problem-Solving Skills of Physics Bachelor Candidates: An Alternative Learning in the Covid-19 Pandemic

Jurnal Penelitian Fisika dan Aplikasinya, 2020
In this industrial revolution 4.0 era, professional science, technology, engineering, and mathematics (STEM) bachelor must have various skills. One of which is problem-solving skills.
Binar Kurnia Prahani, Ali Hasbi Ramadani, Diah Hari Kusumawati, Nadi Suprapto, Madlazim Madlazim, Budi Jatmiko, Zainal Arifin Imam Supardi, Husni Mubarok, Shabrina Safitri, Utama Alan Deta   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Study of psychometric properties of problem-solving skills questionnaire heppner and petersen in primary school students of birjand

مجله علوم روانشناختی, 2022
Background: Because research shows that reducing problem solving skills causes problems such as reduced academic achievement and academic achievement in elementary students. Although these dimensions and constituent components have been identified, there
shirin chaji, majid ebrahimpour, majid pakdaman, hamid taheri   +3 more
doaj  

Profile of Students’ Problem Solving Skills and the Implementation of Assisted Guided Inquiry Model in Senior High School

Studies in Learning and Teaching, 2020
The purpose of this research to analyze profile students’ problem solving skill and the implementation of assisted guided inquiry at senior high school. The type of research is used the preliminary research method with data collection techniques such as ...
Muslimah Cindikia, Hainur Rasyid Achmadi, Binar Kurnia Prahani, Saiyidah Mahtari   +3 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Elevating Teachers’ Competence through the Development of Instructional Media Oriented to Problem-solving Skills with the Aid of Articulate Storyline

Engagement: Jurnal Pengabdian Kepada Masyarakat
With rapid technological advancement, integrating technology into education becomes increasingly important. It is thus imperative for teachers to master satisfactory competence in improving students' problem-solving skills.
Rafiantika Megahnia Prihandini, Susi Setiawani, Yuli Feri Widyawati   +2 more
doaj   +1 more source