Advanced Science, EarlyView.This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang +7 more
wiley +1 more source
Mediating Roles of Self-Control and Social Support in the Relationship Between Problematic Internet Use and Depression Among Korean Children and Adolescents. [PDF]
J Korean Acad Child Adolesc PsychiatryLee C, Park S.
europepmc +1 more source
p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway
Advanced Science, EarlyView.This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa +23 more
wiley +1 more source
Impact of daily activity allocation on problematic internet use among university students: A compositional perspective. [PDF]
J Behav AddictWang Y, Liu Y, Ren T, Li J.
europepmc +1 more source
Advanced Science, EarlyView.A computationally designed, cobalt‐free maraging steel tailored for additive manufacturing achieves an ultra‐high tensile strength of 2.3 GPa with 5.7% elongation. This exceptional strength‐ductility synergy stems from high‐density core‐shell Ni3Ti/NiAl nanoprecipitates, a crack‐resistant composition, and a fine equiaxed grain structure enabled by ...
Hu Li +6 more
wiley +1 more source
From withdrawal to web: A cross-sectional study of Hikikomori tendencies, social cynicism, and problematic internet use among young adults in Singapore. [PDF]
Int J Soc PsychiatryMorshidi I +3 more
europepmc +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, EarlyView.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
The impact of loneliness on depression among college students: the mediating role of problematic internet use and the moderating role of perceived social support. [PDF]
BMC Public HealthXie ZL, Gan KP, Li J, Qin LW, Wu YT.
europepmc +1 more source
A Self‐Organized Liquid Reaction Container for Cellular Memory
Advanced Science, EarlyView.How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee +4 more
wiley +1 more source