Results 91 to 100 of about 2,052,150 (308)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Parallel Manipulation Argument [PDF]

, 2016
Matt King has recently argued that the manipulation argument against compatibilism does not succeed by employing a dilemma: either the argument infelicitously relies on incompatibilist sourcehood conditions, or the proponent of the argument leaves a ...
Cyr, Taylor W.
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The use of Human Subjects in Biomedical Research: A Problematic Scientific Past Shapes Present Ethical Challenges [PDF]

, 2012
The ethics of human experimentation is a relatively new phenomenon in medicine. The Nuremberg Code and the Helsinki Declaration focused on informed consent in human experimentation.
Pawlik, Timothy M.
core   +1 more source

A preliminary investigation into the prevalence and prediction of problematic cell phone use [PDF]

, 2014
Background and aims Likening mobile phone use dependency to the classification of excessive behaviors may be necessarily equivalent in seriousness to previously established addictions such as problematic computing or excessive gambling.
Amiel T, Anastasi A, Baumeister F R, Baumeister F R, Bessiere K, Bianchi A, Bonetti L, Brenner V, Brickfield C F, Cloninger C R, Davis C, DiClemente C, Fisher S, Forest L A, Gangwisch J E, Gentile D A, Goldberg I, Goldberg L R, Grant J, Greenfield D N, Griffiths M, Griffiths M D, Griffiths M D, Griffiths M D, Griffiths M D, Horvath C W, Lam L, Marlatt G A, Michael M G, Morahan-Martin J, Morrison C, Myers R, Orford J, Pedersen T, Roberts J A, Rosenberg M, Shapira N A, Sue D, Suratt G C, Weaver J B, Wills T A, Wydanto L, Young K S, Young K S, Young K S, Zung W W   +45 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Mobile gaming and problematic smartphone use: a comparative study between Belgium and Finland [PDF]

, 2018
Background and aims: Gaming applications have become one of the main entertainment features on smartphones, and this could be potentially problematic in terms of dangerous, prohibited, and dependent use among a minority of individuals.
Andreassen, Andreassen, Antony, Antony, Bae, Bae, Banerjee, Banerjee, Billieux, Billieux, Billieux, Billieux, Billieux, Billieux, Brislin, Brislin, Campbell, Campbell, Castells, Castells, Cheever, Cheever, Cheng, Cheng, Cortina, Cortina, Dauriat, Dauriat, Donati, Donati, Engl, Engl, Erikson, Erikson, Ferguson, Ferguson, Gentile, Gentile, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Helmstadter, Helmstadter, Hoffner, Hoffner, Hormes, Hormes, Hou, Hou, Jacques, Jacques, Jang, Jang, Jeong, Jeong, Jin, Jin, Junco, Junco, Kaess, Kaess, Kanjo, Kanjo, Kim, Kim, Km, Km, Ko, Ko, Kuo-Hsiang, Kuo-Hsiang, Kuss, Kuss, Kuss, Kuss, Kwon, Kwon, Larche, Larche, Lee, Lee, Lee, Lee, Lee, Lee, Lin, Lin, Liu, Liu, Liu, Liu, Lopez-Fernandez, Lopez-Fernandez, Lovibond, Lovibond, Lovibond, Lovibond, Lovibond, Lovibond, McEvoy, McEvoy, Moreno, Moreno, Mäyrä, Mäyrä, Müller, Müller, Okazaki, Okazaki, Paavilainen, Paavilainen, Park, Park, Phau, Phau, Roberts, Roberts, Rosen, Rosen, Salehan, Salehan, Schmitt, Schmitt, Silver, Silver, Snodgrass, Snodgrass, Srivastava, Srivastava, Su, Su, Szell, Szell, Thomée, Thomée, Thomée, Thomée, Van den Abeele, Van den Abeele, Winn, Winn, Zhou, Zhou   +151 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comprehensive community approach to problematic drug use: building a model [PDF]

, 2015
Se presentan los lineamientos del modelo integral comunitario del abordaje del consumo problemático de drogas. Estos comprenden las dimensiones de integralidad, vulnerabilidad y cuidados en sentido amplio.
Camarotti, Ana Clara, Kornblit, Ana Lia Fortuna   +1 more
core   +3 more sources