Results 81 to 90 of about 396,482 (263)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Child and Adolescent Psychiatry and Mental HealthBackground Bullying, problematic internet gaming, and problematic social media use are concerning phenomena, especially among youth. However, studies including all three of them are scarce.
Franziska Neumayer +4 more
doaj +1 more source
Behind the screens: what underlies the experience of social media as a stressor among adolescents
International Journal of Adolescence and YouthThis study explores which aspects of social media use are associated with experiencing it as a stressor among Norwegian adolescents. Data include 3568 participants (aged 16−18), with a longitudinal subsample (n = 432).
Amanda Iselin Olesen Andersen +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Novel medications for problematic alcohol use
Journal of Clinical InvestigationAlcohol-related harm, a major cause of disease burden globally, affects people along a spectrum of use. When a harmful pattern of drinking is present in the absence of significant behavioral pathology, low-intensity brief interventions that provide information about health consequences of continued use provide large health benefits. At the other end of
Markus Heilig +3 more
openaire +3 more sources
Smartphone addiction, fluid intelligence and working memory in Mexican students
AperturaThe purpose of this article was to determine the association of the level of smartphone addiction with working memory in university students and fluid intelligence in high school graduates.
Ismael Esquivel Gámez +2 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Validation of the Persian Version of the Problematic Internet Use Questionnaire (PIUQ).
Iranian Journal of Psychiatry, 2014 Objective: The most commonly used instrument for the research and treatment of excessive internet use is Young’s Internet Addiction Test (IAT). While the IAT has been translated to several languages (including Persian) and has demonstrated good ...
Hadi Ranjbar +4 more
doaj
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source