Results 51 to 60 of about 2,578,163 (225)

Current Issues in Normative and Legal Regulation of Crime Prevention in Ukraine: Necessity for Improvement

open access: yesBulletin of Kharkiv National University of Internal Affairs
The article reflects the actual state of legal regulation of activities aimed at preventing crimes and other offences in Ukraine. Undoubtedly, there are problematic aspects and a necessity for improvement.
D. S. Melnyk
doaj   +1 more source

Problems and challenges in providing feedback to clinical teachers on their educational performance: A mixed-methods study

open access: yesJournal of Education and Health Promotion, 2019
INTRODUCTION: Given the importance of feedback to improve teachers' educational performance, the current study aimed to identify the challenges and problems involved in providing feedback to clinical teachers on their educational performance.
Sepideh Jamshidian   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Mongolian Studies at the Institute of Oriental Studies of the RAS: Current State and Prospects

open access: yesOriental Studies, 2020
Introduction. The paper briefly reviews the current state and prospects of Mongolian studies at the Institute of Oriental Studies (RAS) that celebrated its 200th anniversary in 2018.
Vladimir V. Grayvoronskiy
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

History and Problems of Education in Afghanistan

open access: yesSHS Web of Conferences, 2016
The formal education institutions in Afghanistan never existed from its establishment (1747) until 1875. Despite that the foundation of modern education was laid in 1875, the number of established schools didn't exceed four until 1919.
Khwajamir Mehtarkhan
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Features of financial support for environmental projects in the green economy

open access: yesЮг России: экология, развитие
The article is devoted to the study of the main forms, methods and problems of financing environmental projects within the framework of the functioning of the green economy, taking into account the specifics of the functioning of the domestic financial ...
N. G. Gadzhiev, A. M. Pleshakov
doaj   +1 more source

COVID-19 and online education: Digital inequality and other dilemmas of rural students in accessing online education during the pandemic [PDF]

open access: yesWorld of Media, 2021
It is widely assumed among academicians that the COVID-19 pandemic has negative implications for the education of school students. However, institutions tried to balance that limitation by using online education, and there exist some inequalities among ...
Malini Srinivasan, Jishnu D., Shamala R.
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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