Results 51 to 60 of about 14,404,588 (272)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

An Investigation into problems encountered by gifted &Talented students and their supervision needs at the pioneers caring centers of Al-Balqa Governorate Jordan. [PDF]

Journal of Islamic Studies, 2010
This study investigated problems encountered by gifted and talented students at the pioneers caring centers in Al-Balqagovcmomteot‘Jordan and their supervision needs.
Omar M. A. Al-Kharabsheh, Ahmad A. Arabyyat   +1 more
doaj  

Software and methodological support for additional professional courses: ideas, problems, monitoring

Вестник Северо-Кавказского федерального университета, 2023
Introduction. The article identifies the possibilities of modeling and using software and methodological support for additional professional courses. Definitions directly related to the process and products of theorization of software and methodological ...
O. D. Prokhorenko, S. V. Morin, O. A. Kozyreva   +2 more
doaj   +1 more source

Quantum Optimization Problems

, 2002
Krentel [J. Comput. System. Sci., 36, pp.490--509] presented a framework for an NP optimization problem that searches an optimal value among exponentially-many outcomes of polynomial-time computations.
C. H. Bennett, D. Deutsch, E. Bernstein, F. Green, H. Buhrman, J. Köbler, L. M. Adleman, L. Valiant, M. Ogiwara, M. W. Krentel, M. W. Krentel, S. Fenner, T. Yamakami, T. Yamakami, Z. Chen   +14 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Current Issues in Normative and Legal Regulation of Crime Prevention in Ukraine: Necessity for Improvement

Bulletin of Kharkiv National University of Internal Affairs
The article reflects the actual state of legal regulation of activities aimed at preventing crimes and other offences in Ukraine. Undoubtedly, there are problematic aspects and a necessity for improvement.
D. S. Melnyk
doaj   +1 more source

Problems and challenges in providing feedback to clinical teachers on their educational performance: A mixed-methods study

Journal of Education and Health Promotion, 2019
INTRODUCTION: Given the importance of feedback to improve teachers' educational performance, the current study aimed to identify the challenges and problems involved in providing feedback to clinical teachers on their educational performance.
Sepideh Jamshidian, Nikoo Yamani, Mohammad Reza Sabri, Fariba Haghani   +3 more
doaj   +1 more source

Spectral Optimization Problems

, 2010
In this survey paper we present a class of shape optimization problems where the cost function involves the solution of a PDE of elliptic type in the unknown domain.
Buttazzo, Giuseppe
core   +1 more source

Women's Experiences of Sexual Problems After Cervical Cancer Treatment: Lessons From Indonesian Women [PDF]

, 2014
Cervical cancer remains the most common cancer among women. It is the second major cause of women’s deaths in Asia as well as in Indonesia. Cervical cancer treatment also raises issues of long-term physical, psychological, sexual, and social ...
Afiyanti, Y. (Yati), Andrijono, A. (Andrijono), Azwar, A. (Azrul), Setyowati, S. (Setyowati)   +3 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source