Results 91 to 100 of about 231,754 (314)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Geochronological and structural constraints on the Cretaceous thermotectonic evolution of the Kraishte zone (Western Bulgaria) [PDF]

, 2010
In the Kraishte region, near the junction of the Balkanides and Dinarides, late Early Cretaceous compression led to the thrusting of the Morava unit over the Struma unit.
Bernoulli, D., Ivanov, Z., Kounov, A., Handler, R., Burg, J. -P., Seward, D.   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multiscale fuzzy modeling and Mathematical problems Related To Tumor Evolution and Medical Therapy

Journal of Fuzzy Set Valued Analysis, 2016
Summary: Many mathematical models have presented for preventing different diseases such as cancers. But the question often asked is why the suggested models are not effective for all people suffering from a special disease. Researchers have mentioned patients' mental and physical conditions not considered by such models.
Pakzad, R., Keshavarz, M., Pakzad, M.
openaire   +2 more sources

A new ghost cell/level set method for moving boundary problems:application to tumor growth [PDF]

, 2008
In this paper, we present a ghost cell/level set method for the evolution of interfaces whose normal velocity depend upon the solutions of linear and nonlinear quasi-steady reaction-diffusion equations with curvature-dependent boundary conditions.
Macklin, Paul, Lowengrub, John S.
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Toward Empirically Investigating Non-Functional Requirements of iOS Developers on Stack Overflow

IEEE Access, 2019
Context: Mobile application developers are getting more concerned due to the importance of quality requirements or non-functional requirements (NFR) in software quality.
Arshad Ahmad, Chong Feng, Kan Li, Syed Mohammad Asim, Tingting Sun   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

An Algorithmic Framework for Multiobjective Optimization

The Scientific World Journal, 2013
Multiobjective (MO) optimization is an emerging field which is increasingly being encountered in many fields globally. Various metaheuristic techniques such as differential evolution (DE), genetic algorithm (GA), gravitational search algorithm (GSA), and
T. Ganesan, I. Elamvazuthi, Ku Zilati Ku Shaari, P. Vasant   +3 more
doaj   +1 more source