Exploring the function and evolution of proteins using domain families [PDF]
, 2009 Proteins are frequently composed of multiple domains which fold independently. These are often evolutionarily distinct units which can be adapted and reused in other proteins.
Reid, A.J., Reid, A J
core
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Computing nash equilibria gets harder : new results show hardness even for parameterized complexity [PDF]
, 2009 In this paper we show that some decision problems regarding the computation of Nash equilibria are to be considered particularly hard. Most decision problems regarding Nash equilibria have been shown to be NP-complete. While some NP-complete problems can
Parsa, Mahdi, Estivill-Castro, Vladimir
core
Factors related to depression in adults with oral health problems in Spain (2017 to 2020) [PDF]
Background: The need to study the link between gender, depression, and oral health is becoming increasingly evident. This study therefore aimed to determine the prevalence and evolution over time of depression among women and men with oral health ...
Cebrino Cruz, Jesús +1 more
core +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Informed consent: still a useful tool in research ethics - DOI: 10.3395/reciis.v2.Sup1.208en
RECIIS, 2008 This article dicusses informed consent (IC): its evolution, its main challenges, and its theoretical assumptions. This process involves the interrelation of IC with the history and evolution of research ethics, and with some abuses committed in ...
Florencia Luna
doaj
On equilibrium in control problems with applications to evolution systems [PDF]
In this paper we examine a mutual control problem for systems of two abstract evolution equations subject to a proportionality final condition. Related observability and semi-observability problems are discussed. The analysis employs a vector fixed-point
Precup, Radu, Stan, Andrei
core +1 more source
On a Class of Problems Related to Financial Mathematics [PDF]
35Q91; connections with Cox-Ingersoll-Ross equation; Nonautonomous evolution problems; operator semigroups and groups; Primary 47D06; Secondary ...
Goldstein, Gisèle Ruiz +2 more
core +1 more source
Variation in resistance to multiple pathogen species:anther-smuts of Silene uniflora [PDF]
, 2012 The occurrence of multiple pathogen species on a shared host species is unexpected when they exploit the same micro-niche within the host. One explanation for such observations is the evolution of pathogen-specific resistances that segregate the host ...
Pedersen, Amy +4 more
core +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source