Results 201 to 210 of about 2,396,506 (265)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Retraction for Li et al., Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Development, validation, and testing of an agriculture support exoskeleton in adjunct to conventional physiotherapy for farm labourers with chronic low back pain: A two-phase, mixed-methods, quasi-experimental pilot study protocol. [PDF]

PLoS One
Kaur G, Qureshi I, Bagde A, Sarode B, Jolhe DA, Nistane VM.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Aquatic vegetation promotes prey diversity but not the diversification of predator phenotypes. [PDF]

Proc Biol Sci
Best RJ, Svitok M, Lürig MD, Hudson CM, Carreira VD, Novikmec M, Leal MC, Seehausen O, Feulner PGD, Matthews B.   +9 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Ranking lambs by feed efficiency - are there changes in ruminal fermentation parameters and enteric methane emissions? [PDF]

Trop Anim Health Prod
Crisóstomo C, Gurgeira DN, Coelho Sartorib LV, de Paz CCP, Ferreira J, Abdalla AL, Costa RLDD.   +6 more
europepmc   +1 more source