Results 211 to 220 of about 2,396,506 (265)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Depth sets the recovery clock: evidence for a time-at-pressure effect in sea lions. [PDF]

Proc Biol Sci
Schwarz JFL, Costa DP, Krüger O, Angelakis N, Baylis A, Chilvers BL, Dormann CF, Fowler SL, Goldsworthy SD, Harcourt R, Hoffman JI, Huckstadt LA, Jeglinski J, McHuron E, McMahon CR, Melin S, Páez-Rosas D, Stoehr S, Trillmich F, Villegas-Amtmann S, Holser RR.   +20 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Hyperedge approximation for stochastic processes on higher-order networks. [PDF]

Proc Natl Acad Sci U S A
Sheng A, McAvoy A, Tian Y, Zhang S, Fontan A, Plotkin JB.   +5 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Recognition of unfamiliar predators in domestic horses through only visual predator cues. [PDF]

PLoS One
Hofacker R, Sebunia N, Pihlblad J, Benderlioglu Z.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Neuropharmacology of language: ERP evidence for catecholaminergic modulation of syntactic processing. [PDF]

Proc Natl Acad Sci U S A
Tan Y, Lewis AG, Schmits IC, Verkes RJ, Cools R, Hagoort P.   +5 more
europepmc   +1 more source

Reply to Huang and Dong: Circuit insights unlock translational potential of peripheral electroacupuncture for epilepsy. [PDF]

Proc Natl Acad Sci U S A
Wang Y, Zhang Q, Wang Y, Chen Z.
europepmc   +1 more source