Results 71 to 80 of about 16,116 (276)

Medical treatment of cardiac arrhythmias in Chagas'heart disease [PDF]

, 1995
There are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d ...
De Paola, Angelo Amato Vincenzo, Gondin, Fernando Antonio Aquino, Hara, Vanderlei, Mendonça, Alayde   +3 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Prognostic Value of Antiarrhythmic Drug Suppression of Electrical Storm Prior to Ventricular Tachycardia Ablation

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 12, Page 3310-3320, December 2025.
Kaplan Meir survival curves comparing the elective and urgent groups from time of ablation. Top Left: Long‐term survival. Top Right: VT‐free survival. Bottom Left: ES‐free survival. Bottom Right: Repeat ablation‐free survival. Long term survival was significantly improved in the elective group.
Rafik Issa, Osama El‐Sayed, Mohammed Al‐Sadawi, Muazzum Shah, Kelly Arps, Amrish Deshmukh, Michael Ghannam, Rakesh Latchamsetty, Krit Jongnarangsin, Thomas Crawford, Aman Chugh, Hakan Oral, Fred Morady, Frank Bogun, Jackson J. Liang   +14 more
wiley   +1 more source

Noninvasive Ph-telemetric Measurement of Gastrointestinal Function [PDF]

, 1991
The purpose of this study was to gain experience with and validate the Heidelberg pH-telemetric methodology in order to determine if the pH-telemetric methodology would be a useful noninvasive measure of gastrointestinal transit time for future ground ...
Tietze, Karen J.
core   +1 more source

Brugada syndrome: 12 years of progression. [PDF]

, 2004
Brugada syndrome is increasingly being recognized in clinical medicine. What started as an electrocardiographic curiosity has become an important focus of attention for individuals working in the different disciplines related to sudden cardiac death ...
Antzelevitch, Charles, Brugada, Josep, Brugada, Pedro, Brugada, Ramon, Hong, Kui, Ohe, Tohru   +5 more
core   +1 more source

Procainamide Is a Specific Inhibitor of DNA Methyltransferase 1*

Journal of Biological Chemistry, 2005
CpG island hypermethylation occurs in most cases of cancer, typically resulting in the transcriptional silencing of critical cancer genes. Procainamide has been shown to inhibit DNA methyltransferase activity and reactivate silenced gene expression in ...
Byron H. Lee, S. Yegnasubramanian, Xiaohui Lin, W. Nelson   +3 more
semanticscholar   +1 more source

Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization

Physiological Reports, Volume 13, Issue 23, December 2025.
Abstract Dispersion of repolarization results from a non‐homogeneous recovery of excitability in cardiac tissue, and it is an important factor in arrhythmogenesis because it could lead to the initiation and maintenance of a variety of arrhythmias. Antiarrhythmic agents that prolong action potential duration (APD) by selectively blocking specific ion ...
Candido Cabo
wiley   +1 more source

Pharmacology of Antiarrhythmics: Quinidine, Beta-Blockers, Diphenylhydantoin, Bretylium [PDF]

, 1973
The electrophysiologic effects of the antiarrhythmic drugs, presented elsewhere in this symposium, form only one of the bases for the selection of a therapeutic agent in any given clinical situation.
Proctor, Jack D., Wasserman, Albert J.
core   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 994-1014, November 2025.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Bundle Branch Reentrant Ventricular Tachycardia in a Patient with the Brugada Electrocardiographic Pattern

Annals of Noninvasive Electrocardiology, 2003
A 55‐year‐old, previously healthy man presented with an episode of wide QRS tachycardia that had left bundle branch morphology and left superior axis. His electrocardiogram in sinus rhythm showed characteristic Brugada pattern with coved type ST‐segment (
Alexander Mazur, Zaza Iakobishvili, Jairo Kusniec, Boris Strasberg   +3 more
doaj   +1 more source