Results 81 to 90 of about 16,116 (276)

A review on dronedarone: Pharmacological, pharmacodynamic and pharmacokinetic profile

Journal of Acute Disease, 2016
Dronedarone, a benzofuran containing chemical compound, is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It is prescribed to the cardiovascular patients who have paroxysmal or persistent atrial fibrillation to lower ...
Farah Iram, Sadaf Ali, Aftab Ahmad, Shah Alam Khan, Asif Husain   +4 more
doaj   +1 more source

Left atrial size after cardioversion for atrial fibrillation: effect of external DC shock [PDF]

, 2003
OBJECTIVE: The aim of this study was to evaluate the effect of external direct current (DC) shock on left atrial (LA) dimension and volumes after cardioversion for atrial fibrillation, and the relation between LA size and atrial function.
L. Bonetti, MATTIOLI, Anna Vittoria, MATTIOLI, Giorgio, S. Bonatti   +3 more
core   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner, Elena Arutyunova, Duong T. Bui, Ling Han, Appan Srinivas Kandadai, Bing Bai, Howard S. Young, Lara K. Mahal, John S. Klassen, M. Joanne Lemieux   +9 more
wiley   +1 more source

Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography.

PLoS ONE, 2019
Human butyrylcholinesterase (HuBChE) is being developed as a therapeutic for protection from the toxicity of nerve agents. An enriched source of HuBChE is Cohn fraction IV-4 from pooled human plasma.
Lawrence M Schopfer, Oksana Lockridge, Emilie David, Steven H Hinrichs   +3 more
doaj   +1 more source

Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison.

Academic Emergency Medicine, 2010
OBJECTIVES The objective was to compare the effectiveness of intravenous (IV) procainamide and amiodarone for the termination of spontaneous stable sustained ventricular tachycardia (VT).
K. Marill, I. deSouza, D. Nishijima, E. Senecal, G. Setnik, T. Stair, J. Ruskin, P. Ellinor   +7 more
semanticscholar   +1 more source

GT61 β‐1,2‐xylosyltransferases define a conserved xylan modification in gymnosperm and Arabidopsis primary cell walls

The Plant Journal, Volume 124, Issue 3, November 2025.
SUMMARY Plant primary and secondary cell walls differ in molecular composition, structure and mechanical properties. While secondary wall xylan has been extensively characterised, the structure of xylan in primary walls remains less well understood, particularly in gymnosperms.
Henry Temple, Yoshihisa Yoshimi, Katharine Davis, Theodora Tryfona, Aleksandra Liszka, Henry Yates, James Andrew London, Alberto Echevarría‐Poza, Joel Wurman‐Rodrich, Li Yu, Glenn Thorlby, Nikolaj Spodsberg, Kyrin R. Hanning, Christina Fleischmann, Xiaolan Yu, Katherine Stott, Kristian B. R. M. Krogh, Mathias Sorieul, Nadine Anders, Paul Dupree   +19 more
wiley   +1 more source

Drug-induced lupus

Indian Journal of Rheumatology, 2019
Drug-induced lupus erythematosus (DILE) is an important differential to consider in a clinical setting of mild lupus. Numerous drugs ranging from the classically described procainamide and hydralazine to novel biological agents such as anti-tumor ...
Kavadichanda Chengappa G
doaj   +1 more source

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Cell Reports Medicine, 2020
Summary: Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined.
Hugo Bernard, Ana Teijeiro, Almudena Chaves-Pérez, Cristian Perna, Basanthi Satish, Anna Novials, Jennifer P. Wang, Nabil Djouder   +7 more
doaj   +1 more source

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

Journal of Immunology, 1988
Inhibitors of DNA methylation, such as 5-azacytidine, induce gene expression. We have previously reported that cloned T cells treated with 5-azacytidine lose the requirement for Ag and can be activated by autologous HLA-D molecules alone, thus becoming ...
E. Cornacchia, J. Golbus, J. Maybaum, J. Strahler, Samir M. Hanash, B. Richardson   +5 more
semanticscholar   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, Volume 26, Issue 20, October 31, 2025.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source