Results 111 to 120 of about 683,469 (288)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Procedurally Fair Provision of Public Projects An axiomatic characterization [PDF]
Unanimous voting as the fundamental procedural source of political legitimacy grants veto power to each individual. We present an axiomatic characterization of a class of bidding processes to spell out the underlying egalitarian values for collective ...
Hartmut Kliemt, Werner Güth
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The control of polish courts over the infringements of procedural rules by the national competition authority. Case comment to the judgement of the Supreme Court of 19 August 2009 – Marquard Media Polska (Ref. No. III SK 5/09) [PDF]
The President of the Office of Competition and Consumers Protection (hereafter, UOKiK) issued a decision on 2 June 2006 (RKT-35/2006) finding that Marquard Media Polska has abused its dominant position (breach of Article 8(2)(1), (5) and 7 of the Act of ...
Bernatt, Maciej
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Declarative and procedural tactical knowledge in youth soccer players: an exploratory study in Chile
Pedagogy of Physical Culture and SportsBackground and Study Aim. Tactical knowledge, both declarative and procedural, is an essential component of cognitive development in youth soccer. The aim of this study is to describe and analyze the declarative and procedural tactical knowledge of youth
Ricardo Souza de Carvalho +4 more
doaj +1 more source
This is the first comprehensive treatment of laboratory experiments designed to evaluate economic propositions under carefully controlled conditions.
Charles A. Holt, Douglas D. Davis
core
On Interpolation in Decision Procedures
, 2011 Interpolation means finding intermediate formulae between given formulae. When formulae decorate program locations, and describe sets of program states, interpolation may enable a program analyzer to discover information about intermediate locations and states.
BONACINA, Maria Paola, Moa Johansson
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source