Results 111 to 120 of about 13,380 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

KEWI: A Knowledge Engineering Tool for Modelling AI Planning Tasks

, 2014
This paper introduces the Knowledge Engineering Web Interface (KEWI) which primarily aims to be used for modelling automated planning tasks in a semi-formal framework.
Chrpa, Lukáš, McCluskey, Thomas Leo, Wickler, Gerhard, Gerhard Wickler, McCluskey, T.L., Thomas Leo McCluskey, Lukáš Chrpa   +6 more
core   +1 more source

Object oriented programming and applications of boundary element method in ground vehicle aerodynamics

Computer Assisted Methods in Engineering and Science, 2023
The phenomenal development and popularisation of Object Oriented Programming (OOP) in recent years has created a new dimension in the innovation and implementation of powerful panel method techniques.
Tak Wai Chiu
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Aladin : An abstract machine for integrating functional and procedural programming

, 1996
Pure functional languages have previously been difficult to integrate with the more common procedural or state-transition style of programming. This paper proposes a simple abstract machine, Aladin, that has pure functional language semantics, with ...
Axford, Tom, Joy, Mike
core  

A direction of migrating procedural paradigm to object based architecture by forming cluster of functions using local search heuristics

, 2014
In contrast to procedural programming, object oriented design provides better modularity, manageability and extensibility. Some legacy softwares written in procedural languages phase out of upgrading and support due to an unmanageable design.
Siddik, Md.S., Gias, A.U., Khaled, S.M., Selim, Md., Sakib, K.   +4 more
core   +1 more source

Functional models of procedural programs [PDF]

, 1992
This thesis shows how any Procedural Programming notation may be modelled by a purely Functional notation and discusses the applications and implications of this modelling approach.\ud \ud Existing ad hoc modelling techniques are gathered together within a common framework.\ud \ud The thesis shows that these techniques break down when the state of ...
openaire   +2 more sources