Results 71 to 80 of about 25,381 (246)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2022 Yasuhiro Morimoto Department of Anesthesia, Ube Industries Central Hospital, Ube, Yamaguchi, JapanCorrespondence: Yasuhiro MorimotoDepartment of Anesthesia, Ube Industries Central Hospital, Ube, Yamaguchi, Japan, Tel +81-836-51-9221, Email yasumorimo ...
Morimoto Y
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Ketamine Implicated in New Onset Seizure
Clinical Practice and Cases in Emergency Medicine, 2019 Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation and pain management. A major benefit of using ketamine is the rapid onset and lack of respiratory depression.
Christopher W. Meaden, Stacey Barnes
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Sedation for invasive procedures in paediatrics [PDF]
Archives of Disease in Childhood, 1997 It is inappropriate to subject children to distressing procedures if this can be avoided. Moreover, many procedures may be difficult or unsafe in the uncooperative child. The number of valuable but invasive techniques in use has increased steadily over the years, and to facilitate these, sedative agents are often given.
openaire +2 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
A Checklist to Document Sedation Competency
MedEdPORTAL, 2008 Introduction Pediatric procedural sedation is an area of increasing focus. In practice, many pediatricians may be called upon to provide sedation for children in diverse settings.
Karen Judy, Kathleen Webster
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