Results 71 to 80 of about 327,171 (284)

Avaliação do uso de cetamina para sedoanalgesia de pacientes críticos [PDF]

, 2014
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Cuidados Intensivos e Paliativos, Florianópolis, 2014.Objetivo: Avaliar a eficácia e segurança da cetamina para ...
Rohr, Jaqueline Flores
core  

Capnography During Procedural Sedation and Analgesia with Intramuscular Ketamine in Paediatric Patients

, 2021
Introduction:Capnography is a proven effective tool for procedural sedation and analgesia (PSA); however it is hardly available in developing countries like Iran.
Seyedhossein Seyedhosseini-davarani, Hamideh Akbari, Sepideh Babaniamansour, Ehsan Aliniagerdroudbari, Ehsan Karimialavijeh   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk factors for chloral hydrate sedation failure in pediatric patients: a retrospective analysis [PDF]

Korean Journal of Anesthesiology
Background This study aimed to investigate the risk factors for chloral hydrate sedation failure and complications in a tertiary children’s hospital in South Korea.
Young-Eun Jang, Jung-Bin Park, Pyoyoon Kang, Sang-Hwan Ji, Eun-Hee Kim, Ji-Hyun Lee, Hee-Soo Kim, Jin-Tae Kim   +7 more
doaj   +1 more source

A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation

Clinical and Translational Science, 2021
The clinical effects of remimazolam (an investigational, ultra‐short acting benzodiazepine being studied in procedural sedation) were measured using the Modified Observer’s Assessment of Awareness/Sedation Scale (MOAA/S).
Jie Zhou, Laura Curd, Lauren R. L. Lohmer, Natalie Delpratt, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia D. Schmith   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

GLP-1RA and aspiration risk in moderate sedation for endoscopy

JCA Advances
Study objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) delay gastric emptying, raising concern for aspiration during sedation. Data describing aspiration risk and the safety of moderate sedation in this population are limited.
Lucia Costanza, BA, Emma B. White, BA, Aadya Chaturvedi, BS, Seungyeop Kang, BS, Courtney A. Chau, BS, Kendrick M. Shaw, MD, PhD, Amanda S. Xi, MD   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Nurse-administered procedural sedation and analgesia in the cardiac catheter laboratory : an integrative review

, 2011
Objectives:\ud To identify and appraise the literature concerning nurse-administered procedural sedation and analgesia in the cardiac catheter laboratory.\ud \ud Design and data sources:\ud An integrative review method was chosen for this study.
Rolley, John X., Karen Page, Linda Worrall-Carter, Conway, Aaron, Page, Karen, Worrall-Carter, Linda, Aaron Conway, John X. Rolley, Rolley, John X.; id_orcid   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source