Results 1 to 10 of about 4,916 (258)

Development and analysis of a remimazolam pharmacokinetics and pharmacodynamics model with proposed dosing and concentrations for anaesthesia and sedation

British Journal of Anaesthesia
Background Pharmacokinetic–pharmacodynamic (PK–PD) models of remimazolam and their covariate relationships are useful for understanding drug disposition and predicting drug effects.
Thomas Stoehr, Douglas Eleveld
exaly   +2 more sources

Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent

Frontiers in Pharmacology, 2021
A program to identify novel intravenous sedatives with a short and predictable duration of action was initiated in the late 1990’s by Glaxo Wellcome. The program focussed on the identification of ester-based benzodiazepine derivatives that are rapidly ...
Gavin Kilpatrick
exaly   +3 more sources

Efficacy of remimazolam besylate versus propofol on hemodynamics during anesthetic induction in elderly patients undergoing bronchoscopy: a randomized controlled trial. [PDF]

BMC Anesthesiol
Background The effect of remimazolam besylate versus propofol on hemodynamics during bronchoscopy remains uncertain. Aim To test the hypothesis that remimazolam besylate can provide a more stable hemodynamic profile than propofol in the elderly for ...
Li D, Cheng Y, Zhou Y, Wei S, Fan D.
europepmc   +2 more sources

The effect of obstructive jaundice on the sensitivity of intravenous anesthetic of remimazolam: study protocol for a controlled multicenter trial

Trials, 2022
Background It is well known that obstructive jaundice could affect the pharmacodynamics of some anesthetics, and the sensitivity of some anesthetics would increase among icteric patients. Remimazolam is a new ultra-short-acting intravenous benzodiazepine
Wen Liu, Bin Yang, Jun-Wei Ji, Hua Yang, Hong-Hao Song, Hai-Bo Qiu, Jin-Chao Song   +6 more
doaj   +1 more source

Safety and efficacy of remimazolam besylate in patients undergoing colonoscopy: A multicentre, single-blind, randomized, controlled, phase Ⅲ trial

Frontiers in Pharmacology, 2022
Study objective: The objective of the study was to evaluate the safety and efficacy of remimazolam besylate versus propofol injection in patients undergoing colonoscopy.Design: A multicenter, randomized, non-inferiority, single-blind, parallel-controlled
Ximei Wang, Xiaolei Hu, Nianyue Bai, Lie Li, Lie Li, Min Zhang, Zhigang Cheng, Qulian Guo   +7 more
doaj   +1 more source

Efficacy and safety of remimazolam besilate for sedation in outpatients undergoing impacted third molar extraction: a prospective exploratory study

BMC Oral Health, 2023
Background Dental treatments often cause anxiety, fear, and stress in patients. Intravenous sedation is widely used to alleviate these concerns, and various agents are employed for sedation.
Kana Oue, Aya Oda, Yoshitaka Shimizu, Tamayo Takahashi, Hisanobu Kamio, Utaka Sasaki, Serika Imamura, Eiji Imado, Akari Mukai, Mitsuru Doi, Miyuki Sakuma, Shigehiro Ono, Tomonao Aikawa, Mitsuhiro Yoshida   +13 more
doaj   +1 more source

Clinical Application and Research Progress of Remimazolam for Pediatric Patients

Drug Design, Development and Therapy
Chen Bai, Mingcan Xu, Yan Guo, Yanwu Jin, Xin Zhao Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, People’s Republic of ChinaCorrespondence: Yanwu Jin; Xin Zhao, Department of ...
Xin Zhao, Yanwu Jin, Chen Bai
exaly   +2 more sources

Remimazolam Has Low Oral Bioavailability and No Potential for Misuse in Drug-Facilitated Sexual Assaults, with or Without Alcohol: Results from Two Randomised Clinical Trials

Drugs in R&D, 2020
Background and Objectives Remimazolam is a new ultra-short-acting benzodiazepine currently being developed for intravenous use in procedural sedation, general anaesthesia, and intensive care unit sedation.
Marija Pesic, Thomas Stöhr, Joachim Ossig, Keith Borkett, Martin Donsbach, Van-Anh Dao, Lynn Webster, Frank Schippers   +7 more
doaj   +1 more source

Total intravenous anesthesia management with simultaneous use of remimazolam and propofol: A case series of three patients

SAGE Open Medical Case Reports, 2023
Remimazolam is an ultra-short-acting benzodiazepine anesthetic agent. Because of pharmacodynamic interactions in the sedation effect between benzodiazepines and propofol, the combination of remimazolam and propofol may allow for a dose reduction of each ...
Yuki Watanabe, Shinju Obara, Satoki Inoue   +2 more
doaj   +1 more source

Remimazolam Anesthesia for MitraClip Implantation in a Patient with Advanced Heart Failure

Case Reports in Anesthesiology, 2021
Remimazolam, a novel and ultrashort-acting benzodiazepine, has been available for general anesthesia in Japan. The administration of remimazolam does not induce injection pain, has been reported to have less cardiovascular depressant effects during ...
Tomoe Satoh, Noriaki Nishihara, Yasuaki Sawashita, Sho Ohno, Naoyuki Hirata, Michiaki Yamakage   +5 more
doaj   +1 more source