Results 1 to 10 of about 101,842 (256)

Characterizing trends and patterns in benzodiazepine-related toxicity deaths in Ontario: A descriptive cross-sectional study. [PDF]

PLoS ONE
ObjectivesThe unregulated drug supply in Canada increasingly contains benzodiazepines, particularly those not approved for medical use, raising concerns about toxicity risk, especially when combined with opioids. Therefore, we aimed to describe trends in
Tonya Campbell, Shaleesa Ledlie, Pamela Leece, Joanna Yang, Bisola Hamzat, Gillian Kolla, Nikki Bozinoff, Rob Boyd, Mike Franklyn, Ashley Smoke, Dana Shearer, Tara Gomes   +11 more
doaj   +2 more sources

Utilization of adjunctive anti-seizure medications to facilitate chronic benzodiazepine discontinuation [PDF]

Mental Health Clinician
Introduction When discontinuing benzodiazepines, treating withdrawal symptoms can be challenging. Some anti-seizure medications (ASM) may mitigate withdrawal symptoms. This article reviews the literature regarding adjunctive ASM use during benzodiazepine
Michael R. Dueno, PharmD, Gavin T. Howington, PharmD, Melody Ryan, PharmD, MPH   +2 more
doaj   +2 more sources

Long-term consequences of benzodiazepine-induced neurological dysfunction: A survey

PLoS ONE, 2023
Background Acute benzodiazepine withdrawal has been described, but literature regarding the benzodiazepine-induced neurological injury that may result in enduring symptoms and life consequences is scant.
Alexis D. Ritvo, D. E. Foster, Christy Huff, A. J. Reid Finlayson, Bernard Silvernail, Peter R. Martin   +5 more
doaj   +2 more sources

Toward clarifying ASAM’s inpatient and residential benzodiazepine tapering recommendations [PDF]

Frontiers in Psychiatry
Christopher K. Blazes, Stephen Leung, Doryn Davis Chervin, Bernard Silvernail   +3 more
doaj   +2 more sources

Supporting safe and gradual reduction of long‐term benzodiazepine receptor agonist use: Development of the SAFEGUARDING‐BZRAs toolkit using a codesign approach

Health Expectations, 2022
Introduction Long‐term benzodiazepine receptor agonist (BZRA) use persists in healthcare settings worldwide and poses risks of patient harm. Objective This study aimed to develop an intervention to support discontinuation of long‐term BZRA use among ...
Tom Lynch, Cristín Ryan, Colin Bradley, D. Foster, Christy Huff, Sharon Hutchinson, Nicole Lamberson, Lily Lynch, Cathal Cadogan   +8 more
doaj   +1 more source

The Frequency of Benzodiazepine Use in the Isparta Province

Psychiatry and Clinical Psychopharmacology, 2021
Objective: In the present study, we aimed to determine the frequency of benzodiazepine prescriptions to patients with psychiatric disorders in Isparta Province, Turkey.
Abdullah Akpinar, Ayse Rumeysa Yaman, Kadir Karakus, Inci Meltem Atay, Kadir Demirci   +4 more
doaj   +1 more source

GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

Frontiers in Psychiatry, 2023
Benzodiazepines have been in use for over half a century. While they remain highly prescribed, their unfavorable side-effect profile and abuse liability motivated a search for alternatives.
Elif Engin, Elif Engin
doaj   +1 more source

Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity

, 2022
In this study, a random multiple human tumor cell line screening of an in-stock small-molecule chemical library was performed, and a hit compound, 1,4-benzodiazepine-2,5-dione (BZD, 11a; average 50% growth inhibitory concentration (GI50 = 0.24 μM)) to 60
Yi Dong (440404), Xilei Xie (2902619), Gang Liu (81776), Shiping Fang (2521909), Wenjun Yu (644052), Yao Ma (320034)   +5 more
core   +2 more sources

Comparison of Nitrous Oxide-Oxygen as Inhalation Agent, Midazolam, Ketamine alone and in Combination as Oral Sedative Agents for In-office Paediatric PatientsA Randomised Control Trial [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: In-office pharmacological sedation techniques are best applied to manage an extremely fearful preschooler, especially during primary dentition or a child’s early mixed dentition period.
MONIKA NAGPAL, MOHAN LAL KHATRI, ANIL GUPTA, ANKIT SRIVASTAVA, SHALINI GARG   +4 more
doaj   +1 more source

Exploring trends in benzodiazepine-positive fatal drug overdoses in Tennessee, 2019–2021

Annals of Medicine, 2023
Background Benzodiazepine-positive overdoses increased between 2019 and 2021 in Tennessee. We sought to determine the changes in the number and characteristics of prescription and illicit benzodiazepine-positive fatal drug overdoses during this period ...
Jenna Moses, Jessica Korona-Bailey, Sutapa Mukhopadhyay   +2 more
doaj   +1 more source