Results 31 to 40 of about 79,803 (167)

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

Benzodiazepine usage and patient preference for alternative therapies: A descriptive study

Health Science Reports, 2019
Background and aims The prevalence of chronic benzodiazepine use in primary care settings remains high despite clear evidence of adverse health outcomes resulting from long‐term use and the availability of effective alternative behavioural therapies ...
Fatema‐Tun‐Naher Sake, Keith Wong, Delwyn J. Bartlett, Bandana Saini   +3 more
doaj   +1 more source

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

Frontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An, Mi Jin Park, Maurizio Fava, David Mischoulon, Hyewon Kim, Jihoon Jang, Jin Pyo Hong, Jun Sang Park, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon   +11 more
doaj   +1 more source

The effect of lemborexant on insomnia in patients with psychiatric disorders: Detailed evaluation using the Athens Insomnia Scale

PCN Reports
Aim Chronic insomnia disorder is common and associated with reduced quality of life. Benzodiazepine hypnotics are commonly prescribed for insomnia, but have potential side effects such as concentration impairment, somnolence, and dependence. Lemborexant (
Tomonori Murayama, Yuji Ito, Kenji Narita, Tetsuro Ishida, Shiro Hinotsu, Masahiko Fujita   +5 more
doaj   +1 more source

Benzodiazepines for delirium [PDF]

Cochrane Database of Systematic Reviews, 2009
Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium.To determine the effectiveness and incidence of adverse effects ...
Edmund, Lonergan, Jay, Luxenberg, Almudena, Areosa Sastre   +2 more
openaire   +2 more sources

Crystal structure of 1,5-diethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dithione

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C13H16N2S2, the seven-membered ring adopts a boat conformation, with the two phenylene C atoms representing the stern and the methylene C atom as the prow. The thione S atoms and N-bound ethyl groups lie on the opposite side of the
Abderrahman Lamkaddem, Mohamed Harcharras, Abdelillah Shaim, Hafid Zouihri, Bousselham Echchahed, Wenhua Bi   +5 more
doaj   +1 more source

Preliminary Investigation of Pharmacist-Delivered, Direct-to-Provider Interventions to Reduce Co-Prescribing of Opioids and Benzodiazepines among a Medicare Population

Pharmacy, 2020
Co-prescribing of opioids and benzodiazepines can lead to overdoses and mortality. This retrospective study analyzed prescription claims data collected in 2016.
Jennifer M. Bingham, Ann M. Taylor, Kevin P. Boesen, David R. Axon   +3 more
doaj   +1 more source

The relationship between self-reported substance use and psychiatric symptoms in low-threshold methadone maintenance treatment clients

Harm Reduction Journal, 2011
Background Ongoing psychiatric symptoms and substance use are common difficulties experienced by clients enrolled in methadone maintenance treatment (MMT).
Barrett Sean P, Fulton Heather G, MacIsaac Cindy, Stewart Sherry H   +3 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

Symptom-Triggered Alcohol Detoxification Compared to Fixed-Dose Regimen of Benzodiazepines: A Retrospective Case–Control Study

Brain Sciences
Background: Alcohol withdrawal syndrome is a common clinical challenge that may lead to significant complications if not properly managed. Symptom-triggered therapy (STT) represents a promising alternative to fixed-dose regimens (FDRs) providing ...
Laurent Becciolini, Fabienne Wehrli, Jens Kronschnabel, Carolina Wiesendanger, Norbert Scherbaum, Patrik Roser   +5 more
doaj   +1 more source