Results 31 to 40 of about 132,663 (305)

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]

, 2017
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa, Kaufman, Daniel L, Middleton, Blake, Tian, Jide   +3 more
core   +1 more source

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin, Hell, Johannes Wilhelm, Matt, Lucas, Rogawski, Michael A   +3 more
core   +3 more sources

Benzodiazepine use in physicians: retrospective 5-year nationwide study in Taiwan

BJPsych Open
Background Benzodiazepine use among physicians is an important public health issue related to physicians’ well-being and patient safety. Aims This study aimed to evaluate the patterns and correlates of benzodiazepine use in physicians by comparing ...
Wan-Ju Cheng, Yin-Chieh Chuang, Hsuan-Ching Wang, Hei-Tung Yip, Cheng-Li Lin, Cynthia Wei-Sheng Lee   +5 more
doaj   +1 more source

Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self‐Report Questionnaire

Neuropsychopharmacology Reports, 2021
Aims Benzodiazepine receptor agonists (BZ‐RAs) are frequently prescribed to treat insomnia; however, their long‐term use is not recommended. To introduce an appropriate pharmaco‐therapy, the current state and background factors of BZ‐RAs' dependence must
Mai Yamamoto, Ken Inada, Minori Enomoto, Mitsunari Habukawa, Takahisa Hirose, Yuichi Inoue, Jun Ishigooka, Yuichi Kamei, Tsuyoshi Kitajima, Masayuki Miyamoto, Hideto Shinno, Katsuji Nishimura, Motohiro Ozone, Masahiro Takeshima, Mayumi Suzuki, Hidehisa Yamashita, Kazuo Mishima   +16 more
doaj   +1 more source

Treatment strategy for insomnia disorder: Japanese expert consensus

Frontiers in Psychiatry, 2023
PurposeThere is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently ...
Yoshikazu Takaesu, Yoshikazu Takaesu, Hitoshi Sakurai, Yumi Aoki, Yumi Aoki, Masahiro Takeshima, Kenya Ie, Kenya Ie, Kentaro Matsui, Kentaro Matsui, Tomohiro Utsumi, Tomohiro Utsumi, Akiyoshi Shimura, Isa Okajima, Nozomu Kotorii, Nozomu Kotorii, Hidehisa Yamashita, Masahiro Suzuki, Kenichi Kuriyama, Kenichi Kuriyama, Eiji Shimizu, Eiji Shimizu, Kazuo Mishima, Koichiro Watanabe, Ken Inada   +24 more
doaj   +1 more source

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil

Frontiers in Psychiatry, 2022
IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous ...
Rebecca Casari, Antonio Metastasio, Lorenzo Zamboni, Lorenzo Zamboni, Martino Biasioli, Simone Campagnari, Fabio Lugoboni   +6 more
doaj   +1 more source

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons [PDF]

, 2016
Zolpidem, a GABAA receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors.
Brickley, SG, Franks, NP, Harding, EC, Uygun, DS, Vyssotski, AL, Wisden, W, Ye, Z, Yu, X, Yustos, R, Zecharia, AY   +9 more
core   +4 more sources

‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use

Health Expectations
Background Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch, Cristín Ryan, Christy Huff, D. E. Foster, Cathal Cadogan   +4 more
doaj   +1 more source

Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories

Drug and Alcohol Dependence Reports
Purpose: This study examined whether co-prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin or norepinephrine reuptake inhibitors (SNRI)s with benzodiazepines is associated with differences in benzodiazepine prescriptions both ...
Kerry L. Kinney, Eliseu da Cruz Moreira-Junior, Laís F. Berro, Matthew C. Morris, James K. Rowlett   +4 more
doaj   +1 more source