Results 51 to 60 of about 79,764 (263)
Epilepsia, EarlyView.Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr +4 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin +3 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless +8 more
wiley +1 more source
Benzodiazepine-Induced Congenital Malformations
Pediatric Neurology Briefs, 1990 The potential teratogenic properties of benzodiazepine (BZD) intake during early pregnancy were investigated at the Departments of Pediatrics, Pathology and Genetics at Goteborg University, Sweden.
J Gordon Millichap
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden +5 more
wiley +1 more source
The Pharmacology of Anxiolytics
South African Family Practice, 2010 Given that anxiety disorders are common and chronic and often co-morbid with both medical and psychiatric conditions, effective and safe anxiolytic drugs are in great demand.
Kim Outhoff
doaj +1 more source
Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats
Epilepsia, EarlyView.Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire +7 more
wiley +1 more source
Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors
Frontiers in Molecular Neuroscience, 2018 γ-aminobutyric acid (GABA) pathways play an important role in neuronal circuitry formation during early postnatal development. Our previous studies revealed an increased risk for adverse neurodevelopmental consequences in animals exposed to ...
Hana Kubová +8 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal +47 more
wiley +1 more source