Results 51 to 60 of about 101,842 (256)

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

Comparison of Benzodiazepine Derivatives in Intravenous Sedation [PDF]

, 1997
P(論文)The usefulness and characteristics of diazepam, flunitrazepam, and midazolam, a benzodiazepine derivative, in intravenous sedation during oral surgical procedures under local anesthesia were studied for 31 patients (10 diazepam, 13 flunitrazepam ...
24957, 24956, 24959, 24958, 工藤, 勝, 大桶, 華子, 24960, 24962, 新家, 昇, 館山, 千都世, 24961, 河野, 峰, 24963, 國分, 正廣, 安孫子, 勲, 河合, 拓郎   +15 more
core  

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Benzodiazepine usage and patient preference for alternative therapies: A descriptive study

Health Science Reports, 2019
Background and aims The prevalence of chronic benzodiazepine use in primary care settings remains high despite clear evidence of adverse health outcomes resulting from long‐term use and the availability of effective alternative behavioural therapies ...
Fatema‐Tun‐Naher Sake, Keith Wong, Delwyn J. Bartlett, Bandana Saini   +3 more
doaj   +1 more source

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

Frontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An, Mi Jin Park, Maurizio Fava, David Mischoulon, Hyewon Kim, Jihoon Jang, Jin Pyo Hong, Jun Sang Park, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon   +11 more
doaj   +1 more source

Treatment of benzodiazepine dependence

, 2019
Introduction and Aims: The consumption of benzodiazepines, including Z‐drugs, can undermine recovery from addictions and other high prevalence psychiatric conditions. They are negatively associated with functional and economic performance, and contribute
MacDonald, Tim
core   +1 more source

Electroconvulsive Therapy for Catatonia in Autistic and Non‐Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self‐Injury Outcomes

Autism Research, EarlyView.
ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith, Maria Bonnee, Sarah Marler, Seri Lim, D. Catherine Fuchs, Rafael Tamargo, Isaac Baldwin, Christopher Maley, Ashley VanHaverbeck, Courtney Hamilton, Timothy Adegoke, Haozheng Xu, Jinyuan Liu, Zachary J. Williams, Jo Ellen Wilson, James Luccarelli   +15 more
wiley   +1 more source

Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding

, 1986
A low molecular weight fraction of human urine (less than 500 daltons) which both inhibits monoamine oxidase and benzodiazepine binding to central and peripheral receptors has been purified by ethyl acetate extractions, HPLC and thin layer chromatography.
Elsworth, J.D., Glover, V., Sandler, M., Goodwin, B.L., Clow, A., Dewar, D.   +5 more
core   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Synthesis of 1,4-benzodiazepine-2,5-diones by base promoted ring expansion of 3-aminoquinoline-2,4-diones

, 2016
An unprecedented reactivity of 3-aminoquinoline-2,4-diones is reported. Under basic conditions, these compounds undergo molecular rearrangement to furnish 1,4-benzodiazepine-2,5-diones.
Urankar, Damijana, Srholcová, Anna, Martin Gazvoda (1676941), Košmrlj, Janez, Filip Křemen (3336132), Gazvoda, Martin, Karel Proisl (3336126), Damijana Urankar (1800889), Stanislav Kafka (3030369), Proisl, Karel, Křemen, Filip, Kafka, Stanislav, Anna Srholcová (3336129), Antonín Klásek (3336135), Janez Košmrlj (1676947), Klásek, Antonín   +15 more
core   +1 more source