Results 61 to 70 of about 101,842 (256)

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks inmammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 [PDF]

, 2005
SJG-136, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine bases in a 5'-GATC-3' sequence in the DNA minor groove.
Hartley, J.A., Ghadessy, Farid J, De Silva, I.U., Thurston, DE, Thurston, D.E., Clingen, PH, Ghadessy, FJ, Tilby, M.J., De Silva, IU, De Silva, Inusha U, Tilby, Michael J, Hartley, JA, McHugh, Peter J, Ghadessy, F.J., Clingen, Peter H, McHugh, P.J., Tilby, MJ, Hartley, John A, Thurston, David E, Clingen, P.H., McHugh, PJ   +20 more
core   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

The effect of lemborexant on insomnia in patients with psychiatric disorders: Detailed evaluation using the Athens Insomnia Scale

PCN Reports
Aim Chronic insomnia disorder is common and associated with reduced quality of life. Benzodiazepine hypnotics are commonly prescribed for insomnia, but have potential side effects such as concentration impairment, somnolence, and dependence. Lemborexant (
Tomonori Murayama, Yuji Ito, Kenji Narita, Tetsuro Ishida, Shiro Hinotsu, Masahiko Fujita   +5 more
doaj   +1 more source

Benzodiazepine: Epidemiologia, Impiego Clinico e Abuso in Italia e nel Mondo

, 2000
Benzodiazepine: Epidemiologia, Impiego Clinico e Abuso in Italia e nel ...
BARBUI, Corrado
core   +1 more source

A New Resin-Bound Universal Isonitrile for the Ugi 4CC Reaction:  Preparation and Applications to the Synthesis of 2,5-Diketopiperazines and 1,4-Benzodiazepine-2,5-diones

, 2016
The preparation and synthetic applications of a novel resin-bound isonitrile are described. The resin is an example of a novel convertible isonitrile that can be utilized in the Ugi multicomponent reaction.
Andrew M. Fryer (2204689), John A. Josey (1833421), April L. Kennedy (1833409)   +2 more
core   +1 more source

Review of electroanalytical-based approaches for the determination of benzodiazepines [PDF]

, 2019
The benzodiazepine class of drugs are characterised by a readily electrochemically reducible azomethine group. A number are also substituted by other electrochemically active nitro, N-oxide, and carbonyl groups, making them readily accessible to ...
Kevin C. Honeychurch, Honeychurch, Kevin C   +1 more
core   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Plasma and breast milk pharmacokinetics of suvorexant in healthy lactating women

British Journal of Clinical Pharmacology, EarlyView.
Aim This paper aims to evaluate the plasma and breast milk pharmacokinetics of suvorexant, an orexin receptor antagonist used to treat insomnia at a maximum dose of 20 mg, in healthy lactating women. Methods The paper reports on an open‐label Phase 1 study in 12 healthy lactating women.
Jacqueline McCrea, Andrew Litovsky, Prachi Wickremasingha, Nairita Ghosal, Brad Roadcap, Robert Valesky, Robin Lee, Leea D. Reed, Ming Wang, Wei Fang, Rebecca Wrishko   +10 more
wiley   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source