Results 21 to 30 of about 79,764 (263)

Design and synthesis of benzodiazepines as brain penetrating PARP-1 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55 benzodiazepines
Jiang Yu, Wenfeng Gou, Haihua Shang, Yating Cui, Xiao Sun, Lingling Luo, Wenbin Hou, Tiemin Sun, Yiliang Li   +8 more
doaj   +1 more source

Benzodiazepine use in physicians: retrospective 5-year nationwide study in Taiwan

BJPsych Open
Background Benzodiazepine use among physicians is an important public health issue related to physicians’ well-being and patient safety. Aims This study aimed to evaluate the patterns and correlates of benzodiazepine use in physicians by comparing ...
Wan-Ju Cheng, Yin-Chieh Chuang, Hsuan-Ching Wang, Hei-Tung Yip, Cheng-Li Lin, Cynthia Wei-Sheng Lee   +5 more
doaj   +1 more source

Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories

Drug and Alcohol Dependence Reports
Purpose: This study examined whether co-prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin or norepinephrine reuptake inhibitors (SNRI)s with benzodiazepines is associated with differences in benzodiazepine prescriptions both ...
Kerry L. Kinney, Eliseu da Cruz Moreira-Junior, Laís F. Berro, Matthew C. Morris, James K. Rowlett   +4 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use

Health Expectations
Background Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch, Cristín Ryan, Christy Huff, D. E. Foster, Cathal Cadogan   +4 more
doaj   +1 more source

New benzodiazepine and Z-hypnotic users and disability pension: an eight-year nationwide observational follow-up study

Scandinavian Journal of Primary Health Care, 2017
Objective: To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. Design: Prescription register study.
Ingunn F. Tvete, Trine Bjørner, Tor Skomedal   +2 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Continuous intravenous flumazenil infusion in a patient with chlordiazepoxide toxicity and hepatic encephalopathy

Journal of Emergencies, Trauma and Shock, 2015
Flumazenil, a benzodiazepine receptor antagonist, is the drug of choice for the diagnosis and treatment of benzodiazepine overdose. We are presenting a patient with chronic alcoholism and alcoholic liver disease, who came with alcohol withdrawal symptoms
Moh′d Al-Halawani, Parijat Sen, Yazan Abdeen, Hamid Shaaban, Allan J Klukowicz, Richard A Miller   +5 more
doaj   +1 more source

Validation of the Patient Health Questionnaire‐2 (PHQ‐2) in Detecting Depression Among Older Adults

AGING MEDICINE, EarlyView.
PHQ‐2 effectively screens for geriatric depression with the optimal cut‐off of 3 points. ABSTRACT Objectives Depression screening tools like the Patient Health Questionnaire‐2 (PHQ‐2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use.
Francesco Salis, Maristella Belfiori, Alessandro Ferrau, Eleonora Bernardini, Emanuele Concas, Anna Maria Lugas, Antonella Mandas   +6 more
wiley   +1 more source