The use of flumazenil for benzodiazepine associated respiratory depression in postanesthesia recovery: risks and outcomes [PDF]
Revista Brasileira de Anestesiologia, 2018 Background and objectives The primary aim was to determine risk factors for flumazenil administration during postanesthesia recovery. A secondary aim was to describe outcomes among patients who received flumazenil.
Troy G. Seelhammer +7 more
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Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundBenzodiazepines have a hypnotic/sedative effect through the inhibitory action of γ-aminobutyric acid type A receptor. Flumazenil antagonizes these effects via competitive inhibition, so it has been used to reverse the effect of benzodiazepines.
Yi Jeong Kim +5 more
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Pharmaceuticals, 2023 Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABAA (type A) receptors for benzodiazepine ligands.
Wei-Hsi Chen +8 more
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Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose [PDF]
Vojnosanitetski Pregled, 2016 Backgound/Aim. Flumazenil is benzodiazepine receptor antagonist. It has been studied for a various indications, including reversal of sedation after surgery or diagnostic procedures, awakening of comatose patients in benzodiazepine overdose, or ...
Đorđević Snežana +4 more
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A NEW APPROACH IN TREATMENT ACUTE IVERMECTIN TOXICITY IN MALE BALB-C MICE
The Iraqi Journal of Agricultural science, 2021 This study was conducted to investigate the potential therapeutic of flumazenil and neostigmine in single and combination in Balb-C mice subjected to ivermectin acute oral toxicity.
F. M. K . Al-Rekabi +2 more
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Re-audit of the use of flumazenil following midazolam-induced conscious sedation
BDJ Open, 2023 Introduction Flumazenil is an antagonist drug of Benzodiazepam (BDZ) that has been used as a reversal agent of midazolam-induced conscious sedation (CS) in both emergency and elective procedures.
Muhammad Syafiq Asyraf Rosli +1 more
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Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABAA Receptors
Brain Sciences, 2020 Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian +4 more
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BMC Anesthesiology, 2023 Background Remimazolam tosilate (RT) is a novel short-acting GABA (A) receptor agonist that has a rapid recovery from procedural sedation and can be fully reversed by flumazenil.
Wenchen Luo +12 more
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Canadian Journal of Gastroenterology, 1991 Tim double-blind, placebo controlled, study assessed the efficacy and safety of flumazenil, a benzodiazepine antagonist, in reversing diazepam-induced sedation in 60 patients undergoing endoscopy.
Lloyd Sutherland +5 more
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Long-term delayed emergence after remimazolam-based general anesthesia: a case report
JA Clinical Reports, 2022 Background Remimazolam is an ultra-short-acting benzodiazepine anesthetic that is antagonized by flumazenil, and it is typically expected to be applied in anesthesia with the purpose of ensuring early postoperative recovery. We report a case of long-term
Tsubasa Takemori +4 more
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