Pharmaceuticals, 2023 Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABAA (type A) receptors for benzodiazepine ligands.
Wei-Hsi Chen +8 more
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Re-sedation using remimazolam anesthesia in patients with multiple injuries during recovery: a case report and literature review [PDF]
Frontiers in MedicineRemimazolam combined with flumazenil can shorten recovery time, but the occurrence of re-sedation may put the patient at risk. Herein, we report a case of a 50-year-old woman who underwent general anesthesia using remimazolam.
Guozun He, Chuangguo Shi, Wei Gao
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Short-term postoperative neurocognitive safety and recovery profiles of remimazolam tosilate combined with flumazenil vs. propofol in cirrhotic patients undergoing endoscopic variceal treatment: a randomized controlled trial [PDF]
Frontiers in MedicineBackgroundPatients with liver cirrhosis frequently exhibit compromised drug metabolism due to hepatic dysfunction, which significantly increases their susceptibility to postoperative neurological adverse events. This study aimed to evaluate the impact of
Yanjie Chen +3 more
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Effect of flumazenil on recovery of memory following recovery of consciousness from general anesthesia with remimazolam: a randomized, open-label, single-center controlled trial [PDF]
JA Clinical ReportsBackground Recovery of consciousness from general anesthesia with remimazolam, an ultrashort-acting benzodiazepine, occurs rapidly. However, patients after recovery of consciousness from general anesthesia with remimazolam often experience periods of ...
Keiko Nobukuni +8 more
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The neurobehavioral effects of flumazenil in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2021 Flumazenil is choosy and competitive GABA receptor blocker that serves as an antidote to benzodiazepines overdose. Its administration in humans and some animal’s model is connected with nervousness, anxiety responses, or seizures attacks.
Ahmed S. Naser, Yasser M. Albadrany
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The effect of midazolam and its reversal flumazenil on sedative and cardiopulmonary variables in sheep [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart.
Ünal YAVUZ, Kerem YENER, Adem ŞAHAN
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The use of flumazenil for benzodiazepine associated respiratory depression in postanesthesia recovery: risks and outcomes [PDF]
Revista Brasileira de Anestesiologia, 2018 Background and objectives The primary aim was to determine risk factors for flumazenil administration during postanesthesia recovery. A secondary aim was to describe outcomes among patients who received flumazenil.
Troy G. Seelhammer +7 more
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Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundBenzodiazepines have a hypnotic/sedative effect through the inhibitory action of γ-aminobutyric acid type A receptor. Flumazenil antagonizes these effects via competitive inhibition, so it has been used to reverse the effect of benzodiazepines.
Yi Jeong Kim +5 more
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Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose [PDF]
Vojnosanitetski Pregled, 2016 Backgound/Aim. Flumazenil is benzodiazepine receptor antagonist. It has been studied for a various indications, including reversal of sedation after surgery or diagnostic procedures, awakening of comatose patients in benzodiazepine overdose, or ...
Đorđević Snežana +4 more
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A NEW APPROACH IN TREATMENT ACUTE IVERMECTIN TOXICITY IN MALE BALB-C MICE
The Iraqi Journal of Agricultural science, 2021 This study was conducted to investigate the potential therapeutic of flumazenil and neostigmine in single and combination in Balb-C mice subjected to ivermectin acute oral toxicity.
F. M. K . Al-Rekabi +2 more
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