Results 11 to 20 of about 13,369 (194)

Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively polisynaptic routes by stimulating inhibitory action of GABA.
Šegrt Zoran, Đorđević Snežana, Jaćević Vesna, Kilibarda Vesna, Vučinić Slavica, Jović-Stošić Jasmina, Potrebić Olivera, Vukčević-Perković Nataša   +7 more
doaj   +5 more sources

Linking GABAergic and Dopaminergic Neurotransmission: Effects on Neural Activity During Human Speech Control. [PDF]

Hum Brain Mapp
A multimodal neuroimaging approach using PET with [11C]flumazenil radioligand combined with PET with [11C]raclopride and functional MRI in healthy humans identified the role of GABAergic neurotransmission and its relationship with dopaminergic function and brain activity during real‐life speaking.
Battistella G, Simonyan K.
europepmc   +2 more sources

Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single-Center Retrospective Cohort Study. [PDF]

DEN Open
ABSTRACT Objectives Remimazolam is a novel ultra–short‐acting benzodiazepine that may offer advantages over conventional sedatives in endoscopic procedures. Evidence for its use in pancreatobiliary endoscopic ultrasonography (EUS) is limited. We compared the efficacy and safety of remimazolam and midazolam in outpatient pancreatobiliary EUS.
Toyonaga H, Masaki M, Yamazaki H, Oka A, Matsuno Y, Nakata H, Takayama S, Nakagawa T, Takayama T, Orino M, Matsumoto H, Sumimoto K, Takeo M, Fukata N, Yamashina T, Shimatani M, Naganuma M.   +16 more
europepmc   +2 more sources

Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose [PDF]

Vojnosanitetski Pregled, 2016
Backgound/Aim. Flumazenil is benzodiazepine receptor antagonist. It has been studied for a various indications, including reversal of sedation after surgery or diagnostic procedures, awakening of comatose patients in benzodiazepine overdose, or ...
Đorđević Snežana, Jović-Stošić Jasmina, Kilibarda Vesna, Šegrt Zoran, Perković-Vukčević Nataša   +4 more
doaj   +1 more source

Comparison of Remimazolam and Midazolam for Sedation During Endoscopic Retrograde Cholangiopancreatography-Related Procedures. [PDF]

DEN Open
ABSTRACT Objectives Remimazolam is an ultra‐short‐acting benzodiazepine recently approved for endoscopic procedures in Japan as a sedative agent. We aimed to compare the efficacy and safety of remimazolam and midazolam for endoscopic retrograde cholangiopancreatography (ERCP)‐related procedures.
Tanisaka Y, Ryozawa S, Ito S, Mizuide M, Fujita A, Watanabe R, Hamamura R, Matsuno Y.   +7 more
europepmc   +2 more sources

A NEW APPROACH IN TREATMENT ACUTE IVERMECTIN TOXICITY IN MALE BALB-C MICE

The Iraqi Journal of Agricultural science, 2021
This study was conducted to investigate the potential therapeutic of flumazenil and neostigmine in single and combination in Balb-C mice subjected to ivermectin acute oral toxicity.
F. M. K . Al-Rekabi, A. Alsadawi, Ali. I. Al-ameedi   +2 more
doaj   +1 more source

Automated Synthesis of [¹⁸F]Flumazenil Application in GABA_A Receptor Neuroimaging Availability for Rat Model of Anxiety

Pharmaceuticals, 2023
Clinical studies have demonstrated that the γ-aminobutyric acid type A (GABAA) receptor complex plays a central role in the modulation of anxiety.
Shiou-Shiow Farn, Kai-Hung Cheng, Yuan-Ruei Huang, Shih-Ying Lee, Jenn-Tzong Chen, Kang-Wei Chang   +5 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

Re-audit of the use of flumazenil following midazolam-induced conscious sedation

BDJ Open, 2023
Introduction Flumazenil is an antagonist drug of Benzodiazepam (BDZ) that has been used as a reversal agent of midazolam-induced conscious sedation (CS) in both emergency and elective procedures.
Muhammad Syafiq Asyraf Rosli, Ellie Heidari   +1 more
doaj   +1 more source

Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]

, 2010
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi, O\u27Dell, Kazuko A, Tokuda, Kazuhiro, Zorumski, Charles F   +3 more
core   +2 more sources