Results 31 to 40 of about 8,172 (206)

Pharmacological Influences on the R2 Blink Reflex Response in Healthy Participants: A Systematic Review

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Pharmacological modulation of the R2 blink reflex was comparable whether responses were elicited using standard patch or concentric electrodes. Across nine studies, noradrenergic and GABAergic interventions produced the most consistent effects, supporting the R2 blink reflex as a sensitive biomarker of trigeminofacial nociceptive processing.
Josh Murphy, Joy Krecke, Celia Morgan, Paul H. Strutton, Kirsty Bannister, Sam W. Hughes   +5 more
wiley   +1 more source

Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

Molecules, 2022
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura, Laurent Tanguy, Bengt Långström, Ludovic Le Meunier, Christer Halldin, Sangram Nag   +5 more
doaj   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, Volume 15, Issue 25, 3 July 2026.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

Flumazenil may improve gait and mentation in dogs presenting with marijuana toxicosis

Frontiers in Veterinary Science
IntroductionAlongside the United States’ growing landscape of legalized recreational marijuana intended for humans, cases of canine marijuana toxicosis have been on the rise.
Alyson H. Fitzgerald, Yuntao Zhang, Samuel Stewart, Scott A. Fritz, Alex M. Lynch, Monique Ramras, Stacy D. Meola   +6 more
doaj   +1 more source

Sedation of Wild Pyrenean Capercaillie (Tetrao urogallus aquitanicus) Using Intramuscular Midazolam

Animals, 2022
Global Positioning System (GPS) tracking offers key information in the study of movement ecology of threatened species. Nevertheless, the placement of GPS devices requires animal capture and handling, which may represent a challenge to the individual’s ...
Olga Nicolás Francisco, Ivan Afonso Jordana, Diego Garcia Ferré, Job Roig Simón, Ana Carolina Ewbank, Antoni Margalida, Irene Sacristán, Kévin Foulché, Emmanuel Ménoni, Carlos Sacristán   +9 more
doaj   +1 more source

Assessment of the Acute Toxicity and Anxiolytic‐Like Effect of α‐Humulene in Adult Zebrafish (Danio rerio)

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges, Italo Moura Barbosa, Jéssica Bezerra Maciel, Aluísio Marques da Fonseca, Jesyka Macedo Guedes, Jane Eire Silva Alencar de Menezes, Gyllyandeson de Araujo Delmondes, Marta Regina Kerntopf, Hélcio Silva dos Santos, Alexandre Magno Rodrigues Teixeira   +9 more
wiley   +1 more source

Prolonged infusion of flumazenil for the reversal of sedation from chlordiazepoxide: a case report

Toxicology Communications
A continuous infusion of flumazenil may be needed to mitigate prolonged sedation from benzodiazepines. Some benzodiazepines have extended durations of action.
Anthony Spadaro, Mehruba Parris, Paul Valestra, Howard A. Greller, Diane P. Calello, Lewis S. Nelson, Christopher W. Meaden   +6 more
doaj   +1 more source

Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively polisynaptic routes by stimulating inhibitory action of GABA.
Šegrt Zoran, Đorđević Snežana, Jaćević Vesna, Kilibarda Vesna, Vučinić Slavica, Jović-Stošić Jasmina, Potrebić Olivera, Vukčević-Perković Nataša   +7 more
doaj   +1 more source

Successful Management of Total Intravenous Anesthesia Using Remimazolam, Dexmedetomidine, and Remifentanil for Airway Stenting Under Rigid Bronchoscopy: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Using intravenous general anesthesia with remimazolam and remifentanil, we successfully performed airway stent placement for cancer‐related airway stenosis without causing hypoxia. ABSTRACT During airway stenting for airway stenosis under rigid bronchoscopy, preservation of spontaneous breathing is desirable.
Yoko Kurihara, Maiko Hosokawa, Kiyoko Bito, Yusuke Ishida, Mariko Saito, Rena Fukura, Katsunori Oe   +6 more
wiley   +1 more source

A Multispecies Systematic and Critical Review of Intranasal Administration in Veterinary Anaesthesia and Emergency Care: Promising Evidence and Overlooked Challenges

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This review evaluates the clinical potential and limitations of intranasal (IN) drug administration in veterinary anaesthesia and emergency care. IN delivery can provide clinically relevant sedation, analgesia and drug reversal, but its success is not universally reliable and is strongly influenced by species‐specific anatomy, formulation ...
Majid Jafarbeglou
wiley   +1 more source