Results 41 to 50 of about 13,369 (194)

In vivo Illustration of Altered Dopaminergic and GABAergic Systems in Early Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundChanges in γ-aminobutyric acid (GABA) function are noted in patients with Parkinson's disease (PD) who have some non-motor impairments. However, dopamine-related GABA function and GABA-related cognitive changes are still unclear.MethodsThirteen
Hirotsugu Takashima, Hirotsugu Takashima, Tatsuhiro Terada, Tatsuhiro Terada, Tomoyasu Bunai, Takashi Matsudaira, Takashi Matsudaira, Tomokazu Obi, Yasuomi Ouchi, Yasuomi Ouchi   +9 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Ligand-gated ion channels [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +150 more
core   +5 more sources

Benzodiazepine poisoning in elderly [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. Benzodiazepines are among the most frequently ingested drugs in self-poisonings. Elderly may be at greater risk compared with younger individuals due to impaired metabolism and increased sensitivity to benzodiazepines. The aim of
Perković-Vukčević Nataša, Vuković-Ercegović Gordana, Šegrt Zoran, Đorđević Snežana, Jović-Stošić Jasmina   +4 more
doaj   +1 more source

Risk factors of aspiration pneumonia in patients with severe benzodiazepine, zopiclone, or zolpidem overdose

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 3, June 2026.
Abstract Background Benzodiazepines, zopiclone, and zolpidem account for the most common hypnotics overdose in Hong Kong. Patients with severe benzodiazepines, zopiclone, or zolpidem overdose presenting in a comatose state are at risk of development of aspiration pneumonia.
Lo Wa Ng, Tin Yat Anthony Chow, Oi Fung Wong, Chi Keung Chan   +3 more
wiley   +1 more source

Sedation for Gastrointestinal Endoscopic Procedures in the Elderly: Getting Safer but Still Not Nearly Safe Enough [PDF]

, 2006
Previously published UK reports showed that excessively large doses of benzodiazepines and opiates were being commonly used to sedate elderly patients for gastrointestinal (GI) endoscopy. This unsafe practice has lead to avoidable morbidity and mortality.
Bell, G. D., Bowles, J, De La Iglesia, Beatriz, Gray, A, Lord, David, Quine, A, Rayward-Smith, Vic, Reynolds, Alan, Romaya, C   +8 more
core  

Orbitofrontal epilepsy: Electroclinical analysis of surgical cases and literature review [PDF]

, 2004
Clinical and electrographic data were reviewed on 2 of our patients with orbitofrontal epilepsy who were seizure free at 5-year follow-up, and on 2 similar patients from the literature.
King, Don W., Loring, David W., Sillay, Karl, Smith, Joseph R., Winkler, Peter   +4 more
core   +1 more source

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, Volume 121, Issue 6, Page 1530-1540, June 2026.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source

Idiopathic Recurrent Stupor, Still an Unsolved Issue [PDF]

, 2015
We report a case of unexplained recurrent stupor for which, given the current knowledge and the lack of easily available diagnostic tools, we were unable to reach a definite diagnosis. In the patient the syndrome was associated with an ominous prognosis.
Avallone, Rossella, Fois, Chiara, Murgia, Bastianino, Murrighile, Raffaela Maria, Sechi, Gianpietro   +4 more
core   +1 more source

GABAA receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [11C]flumazenil

Frontiers in Neuroscience, 2023
IntroductionThe fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated.
Alexander Heinzel, Alexander Heinzel, Alexander Heinzel, Jörg Mauler, Hans Herzog, Frank Boers, Felix M. Mottaghy, Felix M. Mottaghy, Karl-Josef Langen, Karl-Josef Langen, Jürgen Scheins, Christoph Lerche, Bernd Neumaier, Georg Northoff, N. Jon Shah, N. Jon Shah, N. Jon Shah, N. Jon Shah   +17 more
doaj   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source