Results 41 to 50 of about 8,172 (206)
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. [PDF]
PLoS ONE, 2012 Evidence indicates that synchronization of cortical activity at gamma-band frequencies, mediated through GABA-A receptors, is important for perceptual/cognitive processes.
W Gordon Frankle +8 more
doaj +1 more source
Mapping the Clinical Evidence on Remimazolam in Anaesthesia: A Protocol for a Scoping Review
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.ABSTRACT Background Remimazolam is a recently introduced benzodiazepine used for procedural sedation and general anaesthesia. Its pharmacokinetic profile, including rapid metabolism and predictable recovery, has generated interest in its potential advantages compared with traditional sedatives such as midazolam and propofol.
Emma Hansine Vangsgaard Skuldbøl Nilsson +2 more
wiley +1 more source
European Journal of Neuroscience, Volume 64, Issue 1, July 2026.Reduced gamma‐aminobutyric acid (GABAA) receptor availability may augur a role for GABAA inverse agonists for treatment of freezing of gait in Parkinson's disease. ABSTRACT We aimed to explore the relationship between regional gamma‐aminobutyric acid (GABAA) receptor availability, measured with [11C]‐flumazenil brain positron emission tomography (PET ...
Alexander A. Hart +8 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 14, Page 6057-6079, 15 July 2026.Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg +3 more
wiley +1 more source
Journal of Emergencies, Trauma and Shock, 2015 Flumazenil, a benzodiazepine receptor antagonist, is the drug of choice for the diagnosis and treatment of benzodiazepine overdose. We are presenting a patient with chronic alcoholism and alcoholic liver disease, who came with alcohol withdrawal symptoms
Moh′d Al-Halawani +5 more
doaj +1 more source
Molecular Mechanisms and Probe‐Dependent Effects of Clinically Relevant GABAA Receptor Modulators
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Combining molecular dynamics, dynamic pharmacophores, and allosteric network analysis, we reveal that benzodiazepines and Z‐drugs stabilize GABA binding through long‐range TMD–ECD allosteric coupling, while anesthetics directly activate the channel via unique L232/I264 contacts, bypassing GABA.
Marvin Taterra +2 more
wiley +1 more source
Frontiers in Pharmacology, 2018 The ethyl acetate fraction of Quercus incana yielded two new compounds [1 and 2]. The characterization and structure elucidation of these compounds were carried out through various spectroscopic techniques such as mass spectrometry along with one- and ...
Rizwana Sarwar +10 more
doaj +1 more source
Re: Antagonizing the errors of history: bedside experience with flumazenil [PDF]
, 2021 Sara Ebrahimi +1 more
openalex +1 more source
Hong Kong Journal of Emergency Medicine, Volume 33, Issue 3, June 2026.Abstract Background Benzodiazepines, zopiclone, and zolpidem account for the most common hypnotics overdose in Hong Kong. Patients with severe benzodiazepines, zopiclone, or zolpidem overdose presenting in a comatose state are at risk of development of aspiration pneumonia.
Lo Wa Ng +3 more
wiley +1 more source
Gut and Liver, 2014 Background/AimsFlumazenil was administered after the completion of endoscopy under sedation to reduce recovery time and increase patient safety. We evaluated patient satisfaction after endoscopy under sedation according to the timing of a postprocedural ...
doaj +1 more source