Results 51 to 60 of about 13,369 (194)

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa, Joilna Alves Da Silva, Jéssica Bezerra Maciel, Ivana Carneiro Romão, Thais Rocha Cavalcante, Francisco Anderson Nascimento Barros, Nicole de Abreu Bandeira, Emmanuel Silva Marinho, Jane Eire Silva Alencar De Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses Da Silva, Márcia Machado Marinho, Matheus Nunes Da Rocha, Otília Deusdênia Loiola Pessoa, Pedro Henrique Jatai Batista, Andreia Ferreira De Castro Gomes, Alexandre Magno Rodrigues Teixeira, Hélcio Silva Dos Santos   +17 more
wiley   +1 more source

Benzodiazepine receptor binding in cerebellar degenerations studied with positron emission tomography [PDF]

, 1995
We used positron emission tomography with [ 11 C]flumazenil to study gamma‐aminobutyric acid type A/benzodiazepine receptor binding quantitatively in the cerebral hemispheres, basal ganglia, thalamus, cerebellum, and brainstem of 72 subjects, including ...
Albin, Bannister, Berciano, Borit, Brooks, Cohen, Durr, Duvoisin, Eadie, Eadie, Enna, Fearnley, Ferrer, Frey, Gibb, Gilman, Gilman, Haefely, Haefely, Harding, Hochberg, Holthoff, Kanazawa, Kato, Kato, Kish, Kish, Kluin, Koeppe, Koeppen, Koeppen, Kume, Lantos, Matsumoto, Mazière, McCabe, McLeod, Mochizuki, Nakazato, Olsen, Olsen, Olsen, Olsen, Oppenheimer, Palacios, Palacios, Papp, Papp, Papp, Perry, Perry, Polinsky, Price, Quinn, Rosenthal, Savoiardo, Savoiardo, Shinotoh, Spokes, Sung, Takei, Whitehouse   +61 more
core   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He, Hanxiao Xue, Sheng Bi, Yan Wang, Xiaocao Liu, Yixia Li, Zhigeng Chen, Dongdong Rong, Bixiao Cui, Jie Ma, Shaozhen Yan, Jie Lu   +11 more
wiley   +1 more source

Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

Molecules, 2022
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura, Laurent Tanguy, Bengt Långström, Ludovic Le Meunier, Christer Halldin, Sangram Nag   +5 more
doaj   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Flumazenil may improve gait and mentation in dogs presenting with marijuana toxicosis

Frontiers in Veterinary Science
IntroductionAlongside the United States’ growing landscape of legalized recreational marijuana intended for humans, cases of canine marijuana toxicosis have been on the rise.
Alyson H. Fitzgerald, Yuntao Zhang, Samuel Stewart, Scott A. Fritz, Alex M. Lynch, Monique Ramras, Stacy D. Meola   +6 more
doaj   +1 more source

Surgical management of an open humeral fracture in a greater rhea (Rhea americana): Internal placement of a locking compression plate and post‐operative complications

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
SUMMARY A 17‐year‐old, 24‐kg, female greater rhea (Rhea americana) presented with an acute onset of left wing droop. Clinical examination and radiographs revealed an open, simple, displaced, short‐oblique diaphyseal fracture of the distal third of the left humerus.
Pierre Huberdeau, Thomas Coutant, Aram Arslanian, Emeline Maurice, Fouad Stephan, Sylvie Laidebeure, Alexis Lécu   +6 more
wiley   +1 more source

Prolonged infusion of flumazenil for the reversal of sedation from chlordiazepoxide: a case report

Toxicology Communications
A continuous infusion of flumazenil may be needed to mitigate prolonged sedation from benzodiazepines. Some benzodiazepines have extended durations of action.
Anthony Spadaro, Mehruba Parris, Paul Valestra, Howard A. Greller, Diane P. Calello, Lewis S. Nelson, Christopher W. Meaden   +6 more
doaj   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. [PDF]

PLoS ONE, 2012
Evidence indicates that synchronization of cortical activity at gamma-band frequencies, mediated through GABA-A receptors, is important for perceptual/cognitive processes.
W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran   +8 more
doaj   +1 more source