Results 171 to 180 of about 4,901,630 (319)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Determinants of timing performance on the peak procedure

, 2012
The performance of brown shaver hens gallus gallus domesticus, was investigated using a peak procedure as a method to examine the timing abilities of an animal. Peak procedure involves using a combination of peak interval and fixed interval trials, where
McHugh, Mark Edward
core  

Implementing David Procedure in Latin America: Closing the Gap with High-Income Countries. [PDF]

Braz J Cardiovasc Surg
Prieto G, Vanegas J, Guerrero J, Hurtado A, Licht M, Montes L.   +5 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Assessment of pain and post-injection induration in children: A comparative study of cold application, manual pressure, and shot blocker techniques. [PDF]

J Educ Health Promot
Sasireka V, Bhuvaneswari G, Babu S.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Patient-reported experience in device-assisted enteroscopy: Conscious sedation vs. general anesthesia. [PDF]

Endosc Int Open
O'Hara FJ, Leung E, Costigan C, McNamara D.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Civil procedure: LexisNexis questions and answers

, 2016
This book provides an understanding of civil procedure and gives a clear and systematic approach to analysing and answering problem and exam ...
Zillmann, Hugh, Hemming, Andrew
core  

Effective strategies to reduce pain and anxiety in infants during routine needle-related medical procedures. [PDF]

BMC Pediatr
Cato K, Andersson H, Funkquist EL, Enskär K, Golsäter M.   +4 more
europepmc   +1 more source