Results 131 to 140 of about 9,026,347 (309)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Sedation and analgesia for gastrointestinal endoscopy in children

open access: yesZdravniški Vestnik, 2013
Different sedation or anesthesia protocols are available to enable gastrointestinal endoscopic examinations in children. None is optimal. Sedation is organized according to the medical system, resources and the availability of personnel and medication ...
Jernej Brecelj
doaj  

Conducting home visits procedures [PDF]

open access: yes
This procedural guideline must be read in conjunction with Partnerships in Learning Policy Driver (Doc ID: TASED-4-1398), Home Visit Safety Checklist (below), Worker Safety Guidelines (Doc ID: TASED-4-1219), Support for Early Years Home Visits (Doc ID ...

core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Judicial Cooperation Based On a European Evidence Warrant

open access: yesEIRP Proceedings, 2009
The assurance of a better judicial cooperation between European Union Member States is aconstant preoccupation of the Council of Europe, taking into consideration that the European Union has setitself the objective of maintaining and developing an area ...
Mihaela Laura Pamfil
doaj  

following procedures

open access: yesAJN, American Journal of Nursing, 1973
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

On efficient procedures for multi-issue negotiation

open access: yes, 2006
This paper studies bilateral, multi-issue negotiation between self-interested agents with deadlines. There are a number of procedures for negotiating the issues and each of these gives a different outcome.
Fatima, S.S.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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