Results 201 to 210 of about 4,504,012 (319)

Combined Cartilage Procedures After High Tibial Osteotomy: Cartilage Status, Early Functional Recovery, and Short-term Clinical Outcomes. [PDF]

Orthop J Sports Med
Jung SH, Jung M, Chung K, Moon HS, Jeon BH, Kim SH.   +5 more
europepmc   +1 more source

Effect of Orthopedic Resident Surgical Education on Surgical Case Length and Healthcare Costs. [PDF]

J Hand Surg Glob Online
Gomez RW, Valdes KG, Matullo KS.
europepmc   +1 more source

Hidden Costs of Workflow Challenges in Endoscopy Units: Insights from a Multinational Survey. [PDF]

Endosc Int Open
Beilenhoff U, Schlag C, Wichmann D.
europepmc   +1 more source

Characterization of aerosols generated during suspected aerosol-generating procedures in healthcare settings. [PDF]

Antimicrob Steward Healthc Epidemiol
O'Neil CA, Li J, Wallace MA, Raliya R, Wang Y, Leavey A, Bricker TL, Burnham CD, Boon ACM, Biswas P, Babcock HM.   +10 more
europepmc   +1 more source

Exploratory activity-based direct cost analysis of robotic platforms in urologic surgery. [PDF]

J Robot Surg
Picozzi P, Nocco U, Bossi E, Gattuso D, Labate C, Puleo G, Cimolin V.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The impact of the COVID-19 pandemic on diagnostic procedures in hearing healthcare in Brazil: time series analysis and regional inequalities COVID-19 and hearing diagnostics in Brazil. [PDF]

Braz J Otorhinolaryngol
Corrêa Guimarães G, Menino Castilho A, Rodrigues da Silva VA.   +2 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source