A Bioreactor-Based Yellow Fever Virus-like Particle Production Process with Integrated Process Analytical Technology Based on Transient Transfection. [PDF]
Viruses, 2023 Dekevic G +6 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Hyperspectral Imaging For Process Analytical Technology
, 2011 Hyperspectral Imaging (HI) is a valuable tool for online-analysis and control of production processes. HI is an emerging platform technology that integrates spectroscopy and imaging to gain both spectral and spatial information from a sample. The combination with Multivariate Data Analysis (MVA) permits extraction of the relevant information.
Ostertag, Edwin, Kessler, Rudolf W.
openaire +2 more sources
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing. [PDF]
Sci Rep, 2023 Williams T +11 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
PhycologyThe present study provides an exhaustive exploration of twelve macroalgal species from the Adriatic Sea, including seven brown algae (Ericaria amentacea, Fucus virsoides, Cutleria multifida, Cystoseira compressa, Cystoseira corniculata, Gongolaria ...
Aly Castillo +5 more
doaj +1 more source
Real-time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process. [PDF]
Eng Life Sci, 2022 Wang X, Tian Y, Zhang S, Qu H.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
EcoEnergyExploring a simple, rapid, and scalable synthesis method for the synthesis of high loading nonprecious metal sub‐nanometer clusters (SNCs) electrocatalysts is one of the most promising endeavors today.
Di Wu +5 more
doaj +1 more source