Results 121 to 130 of about 1,866,340 (300)

Uncertain R&D, Backstop Technology and GHGs Stabilization [PDF]

This paper analyses optimal investments in innovation when dealing with a stringent climate target and with the uncertain effectiveness of R&D. The innovation needed to achieve the deep cut in emissions is modelled by a backstop carbon-free technology ...
Massimo Tavoni, Valentina Bosetti
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Real-time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process. [PDF]

Eng Life Sci, 2022
Wang X, Tian Y, Zhang S, Qu H.
europepmc   +1 more source

Analytical and Numerical Solution of a Poisson RBC model [PDF]

This paper analyses a RBC model in continuous time featuring deterministic incremental development of technology and stochastic fundamental inventions arriving according to a Poisson process.
Schlegel, Christoph
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Construction of high‐loading WO3‐x sub‐nanometer clusters via orderly‐anchored top–down strategy boost acidic hydrogen evolution

EcoEnergy
Exploring a simple, rapid, and scalable synthesis method for the synthesis of high loading nonprecious metal sub‐nanometer clusters (SNCs) electrocatalysts is one of the most promising endeavors today.
Di Wu, Haoyang Du, Ziyi Liu, G. A. Bagliu, Jianping Lai, Lei Wang   +5 more
doaj   +1 more source

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification. [PDF]

Pharmaceutics, 2021
Kim EJ, Kim JH, Kim MS, Jeong SH, Choi DH.   +4 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Tracing Heavy Metal Dynamics in Mangrove Sediments: A Study from Ujung Kulon National Park

Ilmu Kelautan
The dynamics of heavy metal concentrations in the sediments of mangroves are crucial for understanding the health and sustainability of these ecosystems.
Dienda Shintianata, Ali Arman Lubis, Untung Sugiharto, Faza Putri Andini, Sonia Saraswati Meiliastri, Md Suhaimi Elias   +5 more
doaj   +1 more source

Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process. [PDF]

Sci Rep, 2021
Muhaimin M, Chaerunisaa AY, Bodmeier R.
europepmc   +1 more source