Results 11 to 20 of about 388,989 (251)

Spatial distribution of elements during osteoarthritis disease progression using synchrotron X-ray fluorescence microscopy

Scientific Reports, 2023
The osteochondral interface is a thin layer that connects hyaline cartilage to subchondral bone. Subcellular elemental distribution can be visualised using synchrotron X-ray fluorescence microscopy (SR-XFM) (1 μm).
Xiwei Fan, Kah Meng Lee, Michael W. M. Jones, Daryl Howard, Antonia Rujia Sun, Ross Crawford, Indira Prasadam   +6 more
doaj   +1 more source

Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State

Pharmaceutics, 2021
Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying.
Joris Lammens, Niloofar Moazami Goudarzi, Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Chris Vervaet, Matthieu N. Boone, Thomas De Beer   +7 more
doaj   +1 more source

Model-based optimization of the primary drying phase of oral lyophilizates

International Journal of Pharmaceutics: X, 2020
Oral lyophilizates also called orally disintegrating tablets (ODTs) are a patient friendly and convenient dosage form. They are manufactured by dosing a suspension in blister cups and subsequently freeze-drying these blisters to achieve porous tablets ...
Brecht Vanbillemont, Thomas De Beer
doaj   +1 more source

Model-Based Optimisation and Control Strategy for the Primary Drying Phase of a Lyophilisation Process

Pharmaceutics, 2020
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are ...
Brecht Vanbillemont, Niels Nicolaï, Laurens Leys, Thomas De Beer   +3 more
doaj   +1 more source

Innovative modification of the surface of screen-printed carbon electrodes by nanofilms directly deposited in cold acrylonitrile plasma

Electrochemistry Communications, 2022
This work describes a pioneering example of the application of plasma-enhanced chemical vapor deposition (PECVD) for the direct modification of commercially available screen-printed carbon electrodes (SPCEs) with plasma-deposited (polymerized ...
Maria Madej, Justyna Lipińska, Ryszard Kapica, Aleksandra Kędzierska-Sar, Ewelina Frątczak, Jolanta Kochana, Bogusław Baś, Jacek Tyczkowski   +7 more
doaj   +1 more source

Antibody Concentration Measurement Using Optical Rotation: Toward Process Analytical Technology [PDF]

MATEC Web of Conferences, 2021
The antibody manufacturing process consists of the cell culture process using animal cells and the purification process including several chromatography steps and filtration steps.
Inaba Hidenori, Wakabayashi Kosuke, Tsujimoto Ikuo, Yoshimoto Noriko, Yamamoto Shuichi   +4 more
doaj   +1 more source

Process Analytical Technology for Chromatography [PDF]

Journal of Chromatographic Science, 2006
A major United States Food and Drug Administration effort is devoted to process analytical technology (PAT), which is emerging as the likely "surprise" of the second half of the decade. PAT is an approach to monitoring, manufacturing, and other processes on a continuous rather than discrete basis.
openaire   +2 more sources

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

Pharmaceutics, 2021
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis.
Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, Ashish Kumar, Joris Lammens, Laurens Leys, Brecht Vanbillemont, Jos Corver, Chris Vervaet, Thomas De Beer   +9 more
doaj   +1 more source

Interface engineering of metal nanomaterials enhance the electrocatalytic water splitting and fuel cell performance

Electrochemical Science Advances, 2022
We conclude this review with a perspective of interface engineering strategy for enhancing the activity of metal catalysts for electrocatalytic water splitting and direct alcohol fuel cells (DAFCs).
Xue Jiang, Wen Zhang, Guang‐Rui Xu, Jianping Lai, Lei Wang   +4 more
doaj   +1 more source

Process analytical technology (PAT) for biopharmaceuticals [PDF]

Biotechnology Journal, 2011
Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production. The recommended analytical tools for building in quality, multivariate data analysis, mechanistic modeling, novel models for interpretation of systems biology data and ...
Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF   +6 more
openaire   +3 more sources