Results 31 to 40 of about 388,989 (251)

Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

Engineering in Life Sciences
This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon‐γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their ...
Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone   +12 more
doaj   +1 more source

Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)

CHIMIA, 2009
Process Analytical Technology (PAT) launched by the U.S. Food and Drug Administration (FDA) aims to ensure the quality of pharmaceutical products. One important tool to obtain a deeper process understanding is the use of modern real-time process
Tobias Broger, Res P. Odermatt, Pablo Ledergerber, Bernhard Sonnleitner   +3 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Platinum Clusters Anchored Amorphous NiMo Hydroxide with Collaborative Electronic Transfer for Overall Water Splitting under High Current Density

Advanced Materials Interfaces, 2022
The development of efficient and stable bifunctional catalysts to meet overall water splitting at high current densities is attractive, but also challenging.
Xinyi Zhang, Yi Han, Wenwen Cai, Dan Zhang, Zuochao Wang, Hongdong Li, Yuyao Sun, Yanyun Zhang, Jianping Lai, Lei Wang   +9 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Ultrafine CoPt3 nanoparticles encapsulated in nitrogen‐doped carbon nanospheres for efficient water electrolysis

Electrochemical Science Advances, 2022
Rational design of nanostructures with excellent activity and stability for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) to realize efficient hydrogen production is essential for renewable energy development and conversion. Here,
Junlu Bi, Xuejun Zhai, Jingqi Chi, Xueke Wu, Shaojin Chen, Xinping Wang, Lei Wang   +6 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Direct observation of 3D nitrogen distribution in silicon-based dielectrics using atom probe tomography

Nature Communications
The distribution of nitrogen in semiconductor devices plays a crucial role in tuning their physical and electrical properties. However, direct observation and precise quantification of nitrogen remain challenging because of analytical limitations ...
Byeong-Gyu Chae, Jeong Yeon Won, Young Sik Shin, Dong Jin Yun, Jae min Ahn, Seon Tae Park, Ki-bum Lee, Hokyun An, Mina Seol, I-Jun Ro, Se-Ho Kim, Chunhyung Chung, Eunha Lee   +12 more
doaj   +1 more source

PROCESS ANALYTICAL TECHNOLOGY

In an ideally regulated manufacturing industry, when a process is launched, its progress should be easily monitored and controlled until that process is completed. This means that at any given time, the condition and the quality of the product with respect to yield are transparent and known.
Alok Kumar Srivastav, Priyanka Das
openaire   +2 more sources

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source