Results 31 to 40 of about 1,873,269 (259)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)

CHIMIA, 2009
Process Analytical Technology (PAT) launched by the U.S. Food and Drug Administration (FDA) aims to ensure the quality of pharmaceutical products. One important tool to obtain a deeper process understanding is the use of modern real-time process
Tobias Broger, Res P. Odermatt, Pablo Ledergerber, Bernhard Sonnleitner   +3 more
doaj   +1 more source

WESTT (Workload, Error, Situational Awareness, Time and Teamwork): An analytical prototyping system for command and control [PDF]

, 2007
Modern developments in the use of information technology within command and control allow unprecedented scope for flexibility in the way teams deal with tasks.
B Kirwan, C Baber, C Baber, C Baber, Chris Baber, D Meister, DL Parks, Guy H. Walker, J Anderson, JR Anderson, M Lloyd, Malcolm Cowton, Ministry of Defence, Ministry of Defence, N Moray, Neville A. Stanton, RA North, Robert J. Houghton, S Wasserman, SK Card, SR Atkinson, WD Gray   +21 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Influence of Wet Granulation Parameters on the Compaction Behavior and Tablet Strength of a Hydralazine Powder Mixture

Pharmaceutics, 2023
The aim of this paper was to describe the influence of high-shear wet granulation process parameters on tablet tensile strength and compaction behavior of a powder mixture and granules containing hydralazine.
Oliver Macho, Ľudmila Gabrišová, Adam Guštafík, Kristian Jezso, Martin Juriga, Juraj Kabát, Jaroslav Blaško   +6 more
doaj   +1 more source

Real-time assessment of critical quality attributes of a continuous granulation process [PDF]

, 2013
There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián, De Beer, Thomas, Fonteyne, Margot, Gildemyn, Delphine, Remon, Jean Paul, Vercruysse, Jurgen, Vervaet, Chris   +6 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Direct observation of 3D nitrogen distribution in silicon-based dielectrics using atom probe tomography

Nature Communications
The distribution of nitrogen in semiconductor devices plays a crucial role in tuning their physical and electrical properties. However, direct observation and precise quantification of nitrogen remain challenging because of analytical limitations ...
Byeong-Gyu Chae, Jeong Yeon Won, Young Sik Shin, Dong Jin Yun, Jae min Ahn, Seon Tae Park, Ki-bum Lee, Hokyun An, Mina Seol, I-Jun Ro, Se-Ho Kim, Chunhyung Chung, Eunha Lee   +12 more
doaj   +1 more source

Towards a Comparative Approach to Manuscript Study on the Web: the Case of the Lancelot-Grail Romance [PDF]

, 2011
This paper presents an outline of the on-going Lancelot-Grail Project, an interdisciplinary collaborative research project drawing together, analysing, and making available in text and picture the surviving manuscripts of the popular Arthurian romance ...
Sochats, Ken, Stones, Alison
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source