Results 71 to 80 of about 1,866,340 (300)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Engineering in Life Sciences, 2023 Viable cell concentration (VCC) is an essential parameter that is required to support the efficient cultivation of mammalian cells. Although commonly determined using at‐line or off‐line analytics, in‐line capacitance measurements represent a suitable ...
Johannes Lemke +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Micro-patterning and actuation of phosphonium-based photo-responsive ionogels for micro-fluidic applications [PDF]
, 2011 The concept of “Micro-total-analysis-Systems” or “Lab-on-chip” has emerged over the past 20-years but, despite of the fact their incredible potential to revolutionise analytical science few outputs have reached the market so far[1].
Benito-Lopez, Fernando +3 more
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Acta Pharmaceutica, 2020 This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance ...
Vovko Aleša Dular, Vrečer Franc
doaj +1 more source
Application of near infrared spectroscopy as a process analytical technology [PDF]
, 2017 Book of Abstracts of CEB Annual Meeting 2017info:eu-repo/semantics ...
Ferreira, Eugénio C. +2 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Power Users and Patchworking – an Analytical Approach to Critical Studies of Young People’s Learning with Digital Media [PDF]
, 2008 This paper sets out to problematize generational categories such as ‘Power Users’ or ‘New Millennium Learners’ by discussing these in the light of recent research on youth and ICT.
Dirckinck-Holmfeld, Lone, Ryberg, Thomas
core +2 more sources