Results 141 to 150 of about 1,405,702 (265)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Путеводитель предпринимателя, 2020 The article reveals and substantiates the main directions for improving the organizational and methodological foundations of management in the transition to the information society.
E. S. Yankovskaya
doaj
Development of flexible process-centric web applications: An integrated model driven approach
, 2012 In recent years, Model Driven Engineering (MDE) approaches have been proposed and used to develop and evolve WAs. However, the definition of appropriate MDE approaches for the development of flexible process-centric WAs is still limited.
Bernardi, M.L. +7 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Comparative process mining in education : an approach based on process cubes
, 2015 Process mining techniques enable the analysis of a wide variety of processes using event data. For example, event logs can be used to automatically learn a process model (e.g., a Petri net or BPMN model).
Guo, S. +5 more
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
SYSTEM APPROACH TO INTERNAL QUALITY EDUCATION CONTROL
Высшее образование в России, 2016 One of the main conditions of modern education development is continuous improvement of educational quality management. Raising of state and society requirements to specialists“ education, cardinal law reforms and strengthening of state governing and ...
Alexander N. Shkrebko, Inna V. Ivanova
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
RESEARCH APPROACHES TO THE ANALYSIS OF «MAN-PRODUCTION» RELATIONS
Russian Journal of Economics and Law, 2014 Objective: to identify and describe research approaches, used in the analysis of the relationship between humans and production. Methods: in this work, we have applied the methods of grouping, describing and historical and logical method.
L. A. Otstavnova
doaj