Results 151 to 160 of about 12,308,452 (298)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Perceived Barriers as Key Behavioral Predictors of Medication Adherence in Older Adults with Diabetes in Northern Iran: Insights from the Health Action Process Approach. [PDF]

Patient Prefer Adherence
Dashteban Namaghi A, Bakhtiari A, Ghorbani S, Zeinali A.   +3 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The effect of home-based virtual exercise rehabilitation on myocardial infarction patients using the health action process approach: a randomized controlled trial. [PDF]

BMC Sports Sci Med Rehabil
Fallah Z, Feizi A, Sadeghi M, Hadavi MM, Shahnazi H.   +4 more
europepmc   +1 more source

Association testing for binary trees-A Markov branching process approach. [PDF]

Stat Med, 2022
Wu X, Zhu H.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The process approach and process modeling

, 2017
The aim of the research is to examine existing approaches to process and functional management of the organization and the benefits of process description.
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Determinants of physical activity adoption and maintenance in older adults: A dual process approach. [PDF]

Psychol Sport Exerc
Maher JP, Behler MH, Hevel DJ, Hudgins BL, Kennedy-Malone L, Khan IF, Murray E, Postlethwait EM, Seo Y, Williams K, Labban JD.   +10 more
europepmc   +1 more source

Evaluation of a Pharmacists' Patient Care Process Approach for Hypertension. [PDF]

Am J Prev Med, 2022
Rivera MD, Johnson M, Choe HM, Durthaler JM, Elmi JR, Fulmer EB, Hawkins NA, Jordan JK, MacLeod KE, Ortiz AM, Shantharam SS, Yarnoff BO, Soloe CS.   +12 more
europepmc   +1 more source