Results 41 to 50 of about 126,259 (267)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Bearing fault diagnosis method based on WSST and ISSA-MCNN-BIGRU

Scientific Reports
Rolling bearings constitute essential components in large-scale rotating machinery, nonetheless, their fault diagnosis still encounters significant challenges, including the difficulty of extracting discriminative features, relatively low recognition ...
Shien Dong, Weiyan Tong, Hongwei Bai, Qiang Liu   +3 more
doaj   +1 more source

Dimensionless Scaling for Miniature Traffic Flow at Intersections

IEEE Open Journal of Intelligent Transportation Systems
Scaled robotic experiments offer a cost-effective and observable means to study collective traffic behavior, yet most existing testbeds lack dimensional consistency with full-scale systems.
Yikai Zeng, Chaopeng Tan, Lutz Buschmann, Meng Wang   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

SCBM-Net: a multimodal feature fusion-based dual-channel method for bearing fault diagnosis

Scientific Reports
To address the limitations of single-modal approaches in bearing fault diagnosis under complex operating conditions, this study proposes SCBM-Net—a novel deep learning model based on a dual-channel multimodal fusion architecture.
Qiang Liu, Weiyan Tong, Hongwei Bai, Shien Dong   +3 more
doaj   +1 more source

Hybrid Particle Swarm Optimization for Hybrid Flowshop Scheduling Problem with Maintenance Activities

The Scientific World Journal, 2014
A hybrid algorithm which combines particle swarm optimization (PSO) and iterated local search (ILS) is proposed for solving the hybrid flowshop scheduling (HFS) problem with preventive maintenance (PM) activities.
Jun-qing Li, Quan-ke Pan, Kun Mao
doaj   +1 more source

An Intelligent Control Method for the Low-Carbon Operation of Energy-Intensive Equipment

Engineering, 2023
Based on an analysis of the operational control behavior of operation experts on energy-intensive equipment, this paper proposes an intelligent control method for low-carbon operation by combining mechanism analysis with deep learning, linking control ...
Tianyou Chai, Mingyu Li, Zheng Zhou, Siyu Cheng, Yao Jia, Zhiwei Wu   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source