Results 171 to 180 of about 711,319 (308)
Batch production prediction for the mechanical cutting industry based on process capability. [PDF]
Sci RepXu G +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
, 2011 Process capability indices had been widely used to evaluate the process performance. The process capability index proposed by Chan et al. [2] does take into account of the proximity of the process mean to the target value T for asymmetric tolerance. For
Wu, Shu-Fei
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A study of process capability index using Bayesian approach under different prior
, 2010 碩士隨著全球化的競爭激烈，以及生活水準的提高所帶來消費者對於產品的品質有更進一步的認識與要求的。因此，生產者必須更重視品質管理，以致於能達到或者超過消費者的需求，以提高與同行的競爭力。由於製程能力指標能夠客觀的表現出製程是否有能力製造出符合消費者所需的產品品質。近幾年來，製程能力指標發展逐漸成熟常被製造業品管上廣大的運用。目前最常使用的製程能力指標 、 、 及 等，而本研究的目的在於針對Chan et al.(1988)等學者所提出的製程能力指標 來進行信賴區間長度的估計 ...
曾國裕; Tzeng, Guo-yu
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The foundation of capability modelling: A study of the impact and utilisation of human resources
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research aims at finding a foundation for assessment of capabilities and applying the concept in a human resource selection.
Shekarriz, Mona
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source