Results 61 to 70 of about 711,319 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Process Capability Analysis Using Interval Type-2 Fuzzy Sets

open access: yesInternational Journal of Computational Intelligence Systems, 2017
In some cases, the specification limits of a quality characteristic should be defined under uncertain information. In the literature, process capability analyses have been handled by using type-1 fuzzy sets under fuzziness up to now.
Abbas Parchami   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Identification of key process areas in the production on an e-capability maturity model for UK construction organisations [PDF]

open access: yes, 2010
Uptake of e-procurement by construction organisations has been slow (Martin, 2008). Positive e-business achievements in other industries, point towards the potential for the construction industry to accomplish similar results.
Eadie, Robert   +3 more
core  

CONFIDENCE INTERVALS FOR THE CAPABILITY INDICES Cpm AND Cpmk IN STATIONARY GAUSSIAN PROCESSES INTERVALOS DE CONFIANZA PARA LOS ÍNDICES DE CAPACIDAD Cpm Y Cpmk EN PROCESOS ESTACIONARIOS GAUSSIANOS

open access: yesRevista Colombiana de Estadística, 2006
Process capability indices provide a measure of how a process meets preset specification limits. Procedures to construct confidence intervals for Cpm and Cpmk for stationary gaussian processes show low coverage probabilities.
Guevara Rubén Darío   +1 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Metode DMAIC Sebagai Solusi Pengendalian Kualitas Produksi Sepatu Tambang: Studi Kasus PT Mangul Jaya-Bekasi

open access: yesComTech, 2012
One way to increase profitability internally in PT Mangul Jaya - Bekasi is decreasing any costs produced from poor product quality by producing shoes with good quality.
Hendy Tannady Tan
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Process Capability Analysis for A Multi-process Product

open access: yes, 2010
[[abstract]]In this paper, we propose a flow path to evaluate the process capability of an entire product composed of multiple process characteristics. There are six steps in the flow path.
Chen, K. S.; Hsu, C. H. ; Wu, C. C.
core  

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