Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Government/Industry Summary of the Design Analysis Methods for Vibrations (DAMVIBS) Program [PDF]
The NASA Langley Research Center in 1984 initiated a rotorcraft structural dynamics program, designated DAMVIBS (Design Analysis Methods for VIBrationS), with the objective of establishing the technology base needed by the rotorcraft industry for ...
Kvaternik, Raymond G.
core +1 more source
Analisis Stabilitas dan Kapabilitas Proses Spinning Benang Katun dengan Metode Six Sigma (Studi Kasus PT. Primissima) [PDF]
As a textile company which produces grey, PT. Primissima surely needs high quality yarn which is also produced in its factory as its main basic material. Decline in yarn quality that significantly happened on May until August 2004 causes negative effects
Amri, Sahrial +2 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Characterizing Spatial Patterns of Base Stations in Cellular Networks
The topology of base stations (BSs) in cellular networks, serving as a basis of networking performance analysis, is considered to be obviously distinctive with the traditional hexagonal grid or square lattice model, thus stimulating a fundamental ...
Li, Rongpeng +5 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The article deals with the assessment of production process capability in the serial production of plastic components. The plastic component was used for analysis. Component is used in the automotive industry in car suspension shock absorbers.
Dobránsky Jozef +2 more
doaj +1 more source
An approach to reconcile the agile and CMMI contexts in product line development [PDF]
Software product line approaches produce reusable platforms and architectures for products set developed by specific companies. These approaches are strategic in nature requiring coordination, discipline, commonality and communication.
Botella López, Pere +2 more
core

