Results 81 to 90 of about 2,095,688 (302)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
IMPROVING PERFORMANCE OF BISCUIT PRODUCTION PROCESS THROUGH LEAN SIX-SIGMA AT PT XYZ
Indonesian Journal of Business and Entrepreneurship, 2017 This research aims to analyze waste or loss using the 7-waste approach and value added/non value added activities in the production process at PT. XYZ. This research also aims to evaluate the production process capability and sigma values at PT.
Ahmad Mukti Almansur +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Internext: Revista Eletrônica de Negócios Internacionais, 2015 In the context of emerging companies’ growth, current challenges depend on the local generation of product and process innovations, as well as dynamic capability to generate innovative solutions cooperatively and new globe business models.
Priscila Rezende da Costa +1 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Analysis of spacecraft data [PDF]
A software program for the production and analysis of data from the Dynamics Explorer-A (DE-A) satellite was maintained and modified and new software initiated.
core +1 more source
An approach to reconcile the agile and CMMI contexts in product line development [PDF]
, 2006 Software product line approaches produce reusable platforms and architectures for products set developed by specific companies. These approaches are strategic in nature requiring coordination, discipline, commonality and communication.
Botella López, Pere +2 more
core
Sudden death of effective entanglement
, 2010 Sudden death of entanglement is a well-known effect resulting from the finite volume of separable states. We study the case when the observer has a limited measurement capability and analyse the effective entanglement, i.e.
I. L. Chuang +4 more
core +1 more source