Results 91 to 100 of about 862,516 (284)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

QUALITY DESIGN METHOD USING PROCESS CAPABILITY INDEX

open access: yesDEStech Transactions on Engineering and Technology Research, 2018
Product quality is usually variable because errors of machining and an assembling are also variable. Tolerancing in a mechanical design process is important because it directly affects product quality and manufacturing cost. Many tolerancing methods have been studied.
A. Otsuka, F. Nagata
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A note on the behaviour of the process capability index Cpmk with asymmetric specification limits [PDF]

open access: yes, 1997
The properties of Cpmk in the presence of asymmetric specification limits are discussed. It is shown that Cpmk tends to zero as the process variation increases and vice versa.
Jessenberger, Jutta, Weihs, Claus
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

A flexible resubmitted variable sampling plan for product quality determination using the process loss index

open access: yesProduction Engineering Archives
This research aims to develop a flexible resubmitted sampling plan (RSP) incorporating a process loss index for variable inspection. This model will effectively address product specifications that are affected by variations in target value and lot ...
Darmawan Armin   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Modified Cp and Cpk Indices Based on Left-Truncated Data

open access: yesAxioms
The process capability indices Cp and Cpk are commonly used in industry to evaluate process capability, but they usually require that quality data follow a normal distribution.
Yimin Yin, Bin Yan, Pengfei Liu
doaj   +1 more source

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