Results 71 to 80 of about 54,558 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A Power Transformation for Non-Normal Processes Capability Estimation

open access: yesIEEE Access
The capability of a process is its ability to produce products that meet predefined requirements in industry and it is measured by capability indices. If data are not normally distributed, other techniques for capability estimation should be taken into ...
Silvija Lavrac, Goran Turk
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

MPCI : An R Package for Computing Multivariate Process Capability Indices

open access: yesJournal of Statistical Software, 2012
Manufacturing processes are often based on more than one quality characteristic. When these variables are correlated the process capability analysis should be performed using multivariate statistical methodologies. Although there is a growing interest in
Edgar Santos-Fernandez   +1 more
doaj  

Practical Implementation of Some Process Capability Indices

open access: yes, 2009
製程能力指標是製程品質特性相關分配之參數的函數。製程能力指標Cp, Cpk及Cpm 已經廣泛地被製造業用來評估製程是否達到製造規格或品質的要求,是一個容易運用的績效評估工具。對於製程能力指標的研究大多數集中於點估計,由於抽樣誤差的忽略易導致指標估計值的不可靠。在本文中,針對這些指標提供另一種簡易方便可靠的方法以評估製程的績效。A process capability index is a function of some parameters of some involved distribution ...
Wu, Chin-chuan; 吳錦全; Kuo, Hsin-lin; 郭信霖
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Fuzzy Testing Model Built on Confidence Interval of Process Capability Index CPMK

open access: yesAxioms
A variety of process capability indices are applied to the quantitative measurement of the potential and performance of processes in manufacturing. As it is easy to understand the formulae of these indices, this method is easy to apply.
Wei Lo   +4 more
doaj   +1 more source

Applying process capability indices in six sigma

open access: yes, 2010
博士1970到1980年代間,因日本產品品質的提升,使得它在國際市場深受消費者的喜愛,而美國產品在各地市場的佔有率則節節敗退。摩托羅拉(Motorola)是許多與日本廠商品質競爭失利的公司之一,為了挽回市場佔有率,遂提出六標準差的品質改善策略。在六標準差改善活動中,衡量步驟是一個非常重要的程序,其中標準差個數是常被用於衡量目前品質水準的一個工具。但在產業間,製程能力指標是另一個常被使用來衡量製造業製程水準的工具。企業內部的標準差改善專案是使用標準差個數來衡量品質水準 ...
許昌賢; Hsu, Chang-hsien
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Utility of process capability indices in assessment of quality control processes at a clinical laboratory chain. [PDF]

open access: yesJ Clin Lab Anal, 2021
Dong P   +7 more
europepmc   +1 more source

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