Results 81 to 90 of about 295,857 (298)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Capability Indices for Non-Normal Distribution Using Gini’s Mean Difference as Measure of Variability

IEEE Access, 2016
This paper investigates the efficiency of Gini's mean difference (GMD) as a measure of variability in two commonly used process capability indices (PCIs), i.e., Cp and Cpk.
Muhammad Kashif, Muhammad Aslam, Ali Hussein Al-Marshadi, Chi-Hyuck Jun   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Power Transformation for Non-Normal Processes Capability Estimation

IEEE Access
The capability of a process is its ability to produce products that meet predefined requirements in industry and it is measured by capability indices. If data are not normally distributed, other techniques for capability estimation should be taken into ...
Silvija Lavrac, Goran Turk
doaj   +1 more source

Influence of surgery and rehabilitation conditioning on psychophysiological fitness [PDF]

, 2008
The purpose of this study was to assess changes in psychophysiological fitness following reconstructive knee surgery and early phase (2.5 months) physical rehabilitation. Nine patients (7 male, 2 female; mean age, 29.9 years) electing to undergo anterior
Bailey, A, Gleeson, N, Minshull, C, Parfitt, G, Rees, D   +4 more
core  

Quantum computational capability of a 2D valence bond solid phase [PDF]

, 2011
Quantum phases of naturally-occurring systems exhibit distinctive collective phenomena as manifestation of their many-body correlations, in contrast to our persistent technological challenge to engineer at will such strong correlations artificially. Here
Affleck, Affleck, Akimasa Miyake, Arovas, Bartlett, Bartlett, Brennen, Briegel, Browne, Cai, Chen, Cirac, DiVincenzo, Eckert, Feynman, Ganesh, Griffin, Gross, Gross, Gross, Gu, Hartmann, Katsura, Kennedy, Kieling, Levin, Miyake, Nielsen, Raussendorf, Raussendorf, Smirnova, Sykes, Van den Nest, Verstraete, Vidal, Wei   +35 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Fuzzy-based functional capability indices for simple linear profile [PDF]

Journal of Mahani Mathematical Research
The quality of some processes is defined by a simple linear function between a response and an explanatory variable, which is named a simple linear profile. Various capability indices have been introduced in the literature for these processes.
Zainab Abbasi Ganji
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Fuzzy Testing Model Built on Confidence Interval of Process Capability Index C_PMK

Axioms
A variety of process capability indices are applied to the quantitative measurement of the potential and performance of processes in manufacturing. As it is easy to understand the formulae of these indices, this method is easy to apply.
Wei Lo, Tsun-Hung Huang, Kuen-Suan Chen, Chun-Min Yu, Chun-Ming Yang   +4 more
doaj   +1 more source