Results 101 to 110 of about 2,519,267 (345)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Regional Medical Business Process Optimization Based on Cloud Computing Medical Resources Sharing Environment

Cybernetics and Information Technologies, 2013
The paper elaborates some basic concepts, for example, cloud computing, medical resources sharing, business process optimization, and then points out the problems in the development process of regional health informatization. However, there are many good
Xi A. Bei, Qin B. Qiuli, Huang C. Lei
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Production and Optimisation of Oxygenated Biofuel Blend Components via the Ethanolysis of Lignocellulosic Biomass: A Response Surface Methodology

Energies
In this study, a response surface methodology (RSM) using a central composite design (CCD) was implemented to investigate the influence of process variables on ethyl levulinate (EL) production from the ethanolysis of waste corn cob samples, using ...
Mohamad A. Nahil, Omar Aboelazayem, Scott Wiseman, Neel Herar, Valerie Dupont, Ali Alazzawi, Alison S. Tomlin, Andrew B. Ross   +7 more
doaj   +1 more source

aRNApipe: A balanced, efficient and distributed pipeline for processing RNA-seq data in high performance computing environments [PDF]

, 2016
Arnald Alonso, Brittany N. Lasseigne, Kelly L. Williams, Josh Nielsen, Ryne C. Ramaker, Andrew A. Hardigan, Bobbi E. Johnston, Brian S. Roberts, Sara J. Cooper, Sara Marsal, R Myers   +10 more
openalex   +1 more source

LCG-1 Deployment and usage experience

, 2003
LCG-1 is the second release of the software framework for the LHC Computing Grid project. In our work we describe the installation process, arising problems and their solutions, and configuration tuning details of the complete LCG-1 site, including all ...
Shamardin, L.
core   +1 more source

Computational Complexity of Iterative Processes [PDF]

SIAM Journal on Computing, 1972
Computer Science ...
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Spatially-graded 3D-printed viscoelastic truss metamaterials for impact trajectory control and energy absorption

Theoretical and Applied Mechanics Letters
This study demonstrates that two- and three-dimensional spatially graded, truss-based polymeric-material metamaterials can be designed for beneficial impact mitigation and energy absorption capabilities.
Kaoutar Radi, Raphaël N. Glaesener, Siddhant Kumar, Dennis M. Kochmann   +3 more
doaj   +1 more source

Optimization of Machine Learning Process Using Parallel Computing [PDF]

, 2018
Michal K. Grzeszczyk
openalex   +1 more source