Results 111 to 120 of about 22,284,815 (342)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Applied Sciences, 2019 Cloud computing services that provide computing resources to users through the Internet also provide computing resources in a virtual machine form based on virtualization techniques.
Jueun Jeon +2 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Sensing emotional valence and arousal dynamics through automated facial action unit analysis
Scientific ReportsInformation about the concordance between dynamic emotional experiences and objective signals is practically useful. Previous studies have shown that valence dynamics can be estimated by recording electrical activity from the muscles in the brows and ...
Junyao Zhang +5 more
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Intelligent Systems with ApplicationsWe evaluate a personalized, two-stage comparison-based FER framework on two datasets of low-to-mid-intensity, near-neutral expressions. The framework consistently outperforms FaceReader and Py-Feat.
Junyao Zhang +3 more
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Editorial of Energy-Efficient and Reliable Information Processing: Computing and Storage [PDF]
, 2019 Yongjune Kim
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
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Cybernetics and Information Technologies, 2013 The paper elaborates some basic concepts, for example, cloud computing, medical resources sharing, business process optimization, and then points out the problems in the development process of regional health informatization. However, there are many good
Xi A. Bei, Qin B. Qiuli, Huang C. Lei
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source