Results 131 to 140 of about 2,580,445 (341)

Resilient Stream Processing in Edge Computing

, 2021
Jinlai Xu, Balaji Palanisamy, Qingyang Wang   +2 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Robust Controller to Extract the Maximum Power of a Photovoltaic System [PDF]

Journal of Electrical and Electronics Engineering, 2014
This paper proposes a technique of intelligent control to track the maximum power point (MPPT) of a photovoltaic system . The PV system is non-linear and it is exposed to external perturbations like temperature and solar irradiation.
OULD CHERCHALI Noureddine, MORSLI Abdelkader, BOUCHERIT Mohamed-Seghir, BARAZANE Linda   +3 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Lead-Free NaNbO₃-Based Ceramics for Electrostatic Energy Storage Capacitors

Ceramics
The burgeoning significance of antiferroelectric (AFE) materials, particularly as viable candidates for electrostatic energy storage capacitors in power electronics, has sparked substantial interest.
Sairatun Nesa Soheli, Zhilun Lu, Dongyang Sun, Islam Shyha   +3 more
doaj   +1 more source

Impact of Processing and Analyzing Healthcare Big Data on Cloud Computing Environment by Implementing Hadoop Cluster

, 2016
Sreekanth Rallapalli, Raju Ramakrishna Gondkar, Uma Pavan Kumar Ketavarapu   +2 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Revealing the role of interface disorder in modulating critical current density of Josephson junctions

npj Computational Materials
Suppressing critical current density (J c) fluctuations in Josephson junctions is essential for improving the reproducibility and scalability of superconducting quantum processors.
Chuanbing Han, Huihui Sun, Yonglong Shen, Junling Qiu, Peng Xu, Fudong Liu, Bo Zhao, Xiaohan Yu, Weilong Wang, Shuya Wang, Qing Mu, Benzheng Yuan, Lixin Wang, Chaofeng Hou, Zheng Shan   +14 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source